UW-FHCRC VARIATION DISCOVERY RESOURCE

炎症是与多种疾病相关的最基本的反应之一 常见的人类疾病包括哮喘、慢性阻塞性肺疾病 疾病、冠状动脉疾病和中风。在此应用程序中， 调查人员建议华盛顿大学和华盛顿大学联合开展一个项目 弗雷德·哈钦森癌症研究中心(UW-FHCRC)建立一种变异 发现资源(VDR)专注于发现单核苷酸多态 (SNPs)在人类潜在的炎症反应的基因和途径中。 目标是：(1)建立一个高吞吐量的变异发现小组 这将扫描200多个与炎症有关的基因；(2) 确定常见的可变点、相对频率和单倍型 具有不同进化史的两个种群的这些基因； (3)通过以下途径迅速向生物医学界传播这一信息 国家数据库，如DBSNP和Genbank，并按生成的资源 网站；以及(4)建立人的培训和教育计划 差异分析，提供现场培训以及正式的 研修班。总的来说，这些研究将为以下方面提供丰富的新信息 检测人类DNA变异之间存在的重要关系 序列，以及人类常见疾病风险的变化。(摘要结束)

Inflammation is one of the most basic responses linked to a wide variety of common human disorders including asthma, chronic obstructive pulmonary disease, coronary artery disease and stroke. In this application, the investigators propose a joint program between the University of Washington and the Fred Hutchinson Cancer Research Center (UW-FHCRC) to establish a Variation Discovery Resource (VDR) focused on finding single nucleotide polymorphisms (SNPs) in the genes and pathways underlying inflammatory responses in humans. The goals are: (1) to establish a high throughput variation discovery group that will scan more than 200 of the genes involved in inflammation; (2) to identify the common variable sites, their relative frequencies, and haplotypes in these genes for two populations having different evolutionary historics; (3) to rapidly disseminate this information to the biomedical community via national databases such as dbSNP and Genbank, and by a resource generated website; and (4) to establish a training and education program on human variation analysis that provides on-site training as well as a formalized workshop. Overall, the studies will provide a wealth of new information for testing the important relationships that exist between variations in human DNA sequence, and variations in risk for common human diseases. (End of Abstract)