Bench, Bedside, Business, and Beyond: innovative solutions for AMR diagnostics

该网络B2B2B AMRDx汇集了来自大学（长凳），医院（床边），营利性（企业），政府和非营利组织（超越）的各种研究人员，以应对其中的一些挑战。我们拥有人类、动物和环境AMR方面的专业知识，来自20个不同的国家。该网络的目标如下：首先，该网络创建一个全面的在线AMR诊断开发人员目录（ADDD），以促进该领域的思想交流。其次，该网络扩展了JPIAMR Seq4AMR虚拟基准平台（VBP），使诊断开发人员能够系统地评估他们对一系列高质量基因型（基因组数据）和表型（抗菌素耐药性数据）的诊断，并确定其优势和劣势。第三，该网络确定了新的政策方向，可以通过考虑使用AMR诊断的公共卫生效益来支持诊断的开发和采用。这些进展将帮助AMR诊断跨越“死亡谷”，帮助患者。基于AMR Insights技术页面的开放式在线AMR诊断开发人员目录（ADDD）。基于Seq4AMR网络先前的成就，为VBP开发基因型、表型和元数据以及伴随的细菌分离株标准的研讨会（Raphenya等人，2022）用于管理、选择和策展金标准NGS数据、表型数据和元数据以及VBP的相应细菌分离株的系统方法。传播和路线图开放获取出版物，描述VBP内容，其格式和基准集选择协议。可能的期刊：微生物基因组学或类似内容。一个研讨会，旨在制定监管途径提案，使AMR诊断开发商能够从基于其产品公共卫生益处的激励措施中受益。一份开放获取路线图出版物，描述了拟议的政策。

The network, B2B2B AMRDx, brings together a diverse group of researchers from universities (bench), hospitals (bedside), for-profits (business), governments and nonprofits (beyond), to tackle some of these challenges. We have expertise in human, animal, and environmental AMR, and come from 20 different countries. The networks goals are as follows.First, the network creates a comprehensive online AMR Diagnostics Developer Directory (ADDD) to facilitate exchange of ideas in the field. Second, the network extends the JPIAMR Seq4AMR Virtual Benchmarking Platform (VBP) to allow diagnostics developers to systematically evaluate their diagnostics on a collection of high-quality genotypes (genomic data) and phenotypes (antimicrobial resistance data) and identify their strengths and weaknesses. Third, the network identifies new policy directions that can support diagnostics development and adoption by accounting for the public health benefits of using AMR diagnostics. These developments will help AMR diagnostics cross the "valley of death" and help patients.Expected outcomes:An open, curated online AMR diagnostics developer directory (ADDD), building on AMR Insights' Technology Pages.A workshop to develop the standards for genotypes, phenotypes, and metadata, as well as the accompanying bacterial isolates for the VBP, building on previous achievements of the Seq4AMR network (Raphenya et al, 2022)A systematic approach for the management, selection and curation of gold standard NGS data, phenotype data, and metadata, as well as the corresponding bacterial isolates for the VBP.Communication, dissemination and roadmap open-access publication describing the VBP contents, its format, and the benchmark set selection protocol. Possible journals: Microbial Genomics or similar.A workshop to develop a proposal for a regulatory pathway to allow AMR diagnostics developers to benefit from incentives based on the public health benefits of their products.An open-access roadmap publication describing the proposed policy.