COOPERATIVE MULTICENTER NEONATAL DATA CENTER

描述(改编自申请者的描述)：研究三角 研究所(RTI)建议作为数据协调中心(DCC) 多中心合作新生儿研究网络。高级职员 为该网络推荐了多个数据协调中心 二十五年来，已经完成或正在进行五大 孕产妇/围产期/新生儿研究。W.Kenneth Poole博士， 拟议的首席调查员，曾在11个主要的DCC项目中任职。在……里面 特别是他一直是高频的首席调查员 通风(高保真)和呼吸窘迫综合征(RDS)研究， 阴道感染和早产儿(VIP)研究的共同调查者和IS NICHD幼儿保育研究(SECC)高级统计师 DC倡议研究。A.Vijaya Rao博士，拟议的联合调查员， 首席调查员DC Initiative，是VIP的首席调查员 他是高保真和RDS研究的联合调查员。泰勒·D博士 哈特维尔是一名拟议的联合调查员，目前是首席调查员 对于SECC的DCC，它非常类似于网络的母亲 生活方式(MLS)项目。另外，普尔博士和拉奥博士以及一些建议的 工作人员已经在高保真和RDS上使用了四个当前的网络PI 学习。所有的工作人员都在DCC工作了很多年 项目，包括孕产妇/围产期/新生儿研究。 建议的顾问以及弗兰克·波特·格雷厄姆儿童基金会的工作人员 发展中心(FPG)包括纵向的儿童发展专家 数据分析、心理测量学和健康经济学。RTI工作人员目前 在其他项目中使用所有这些工具。RTI在罗克维尔附近设有办事处 NICHD，并将安排两名具有以下经验的全职网络协调员 新生儿研究和一名秘书，以促进协调和 与NICHD工作人员就该项目进行沟通。RTI计划采取一项 网络在统计设计和统计领域的领导作用 分析、数据收集程序、数据管理和处理， 质量控制、随机化、研究后勤、DCC之间的过渡、 网络通信，以及追踪毒品供应和标本。他们会 使用最先进的数据收集、处理和管理方法， 包括计算机辅助数据收集方法、电子数据 Transfer，一个网站，以及与研究合作者的互联网联系。 RTI的矩阵管理结构，据此可以分配个人工作人员 对于多个项目，提供了相当大的灵活性 在需求高峰期为项目提供额外资源。研究所 协调中心的工作人员在处理现场PI方面有着令人印象深刻的记录 和统计学家参与了出版手稿的开发。

DESCRIPTION (Adapted from the applicant's description): Research Triangle Institute (RTI) proposes to serve as the Data Coordinating Center (DCC) for the Cooperative Multicenter Neonatal Research Network. The senior staff proposed for this Network have directed data coordinating centers for over twenty-five years and have completed or are now conducting five major studies in maternal/perinatal/neonatal research. Dr. W. Kenneth Poole, the proposed Principal Investigator, has served on 11 major DCC projects. In particular he has been the Principal Investigator of the High Frequency Ventilation (HIFI) and Respiratory Distress Syndrome (RDS) studies, Co-Investigator of the Vaginal Infection & Prematurity (VIP) study and is senior statistician on NICHD'S Study of Early Child Care (SECC) and of the DC Initiative studies. Dr. A. Vijaya Rao, a proposed Co-investigator, is Principal Investigator DC Initiative, was Principal Investigator of the VIP study, and was Co-investigator on the HIFI and RDS studies. Dr. Tyler D. Hartwell, a proposed Co-investigator, is currently Principal Investigator for the DCC for the SECC which is very similar to the Network's Maternal Lifestyles (MLS) project. Also, Drs. Poole and Rao and some of the proposed staff have worked with four of the current Network PIs on the HIFI and RDS studies. All of the staff have worked together for many years on DCC projects including the studies in maternal/perinatal/neonatal research. Consultants proposed as well as staff from the Frank Porter Graham Child Development Center (FPG) include experts in child development, longitudinal data analysis, psychometrics, and health economics. RTI staff are currently working with all of these on other projects. RTI has Rockville offices near NICHD and will place two full time Network coordinators with experience in neonatal studies and a secretary to facilitate coordination and communication with NICHD staff on this project. RTI plans to take a leadership role for the Network in the areas of statistical design and analysis, data collection procedures, data management, and processing, quality control, randomization, study logistics, transition between DCCs, Network communications, and tracking drug supplies and specimens. They will use state-of-the-art methods of data collection, processing, and management, including computer assisted data collection methods, electronic data transfer, a Web site, and Internet linkages with the study collaborators. RTI's matrix management structure, whereby individual staff may be assigned to several projects, provides considerable flexibility in allocating additional resources to projects at times of peak needs. Institute coordinating center staff have an impressive record working with site PIs and statisticians in the development of manuscripts for publication.