TRENDS IN TRANS-FATTY ACID INTAKE BETWEEN 1980 AND 1997

描述 （摘自申请人摘要）近年来， 关于美国饮食中反式脂肪酸的潜在健康危害。 饮食中反式脂肪酸的摄入与不健康的转变有关， 血脂谱和冠心病（CHD）在一些 问题研究 尽管一些研究估计了反式脂肪酸的摄入量， 在美国人口中，目前缺乏关于摄入量趋势的数据， 反式脂肪酸在人群中 此外，目前还不清楚， 反式脂肪酸的摄入量可能与其他饮食的变化有关， 非饮食性CHD危险因素与CHD死亡率。 该提案旨在利用新获得的养分数据重新计算 作为明尼苏达心脏调查（MHS）的一部分收集的饮食数据， 反式脂肪酸的摄入趋势。 MHS是一个持续的观测 危险因素和心血管发病率趋势的流行病学研究， 死亡率之间的独立横截面概率样本的 明尼阿波利斯-圣保罗，明尼苏达州，大都会区。 调查是在 1980-1982、1985-1987、1990-1992和1995-1997年。 饮食是心血管疾病的风险之一 作为每项调查的一部分衡量的因素。 在这项研究中，24小时饮食 从MHS参与者收集的召回将使用更新的 食品和营养数据库，包括反式脂肪酸值（16：1，18：1， 18：2，和总）。 重新计算得出的摄入量估计数为： 分析了1980年至2000年期间反式脂肪酸摄入量的时间趋势， 和1997年，并检查反式脂肪酸的时间趋势之间的关系 酸摄入量与其他饮食和非饮食CHD风险的时间变化 冠心病死亡率的变化。 MHS数据提供了一个独特的机会来检查饮食成分 最近才被认为是冠心病的潜在危险因素。

DESCRIPTION (Adapted from the applicant's abstract) In recent years concern has arisen about the potential health hazards of trans-fatty acids in the American diet. Dietary intake of trans-fatty acids has been linked to unhealthy shifts in serum lipid profiles and to coronary heart disease (CHD) in a number of studies. Although several studies have estimated intakes of trans-fatty acids in U.S. populations, presently data is lacking regarding trends in intake of trans-fatty acids in the population. Furthermore, it is unclear how trends in intake of trans-fatty acids may be related to changes in other dietary and non-dietary CHD risk factors and CHD mortality. This proposal aims to utilize newly available nutrient data to recalculate dietary data collected as part of the Minnesota Heart Survey (MHS) to examine trends in intake of trans-fatty acids. The MHS is an ongoing observational epidemiologic study of trends in risk factors and cardiovascular morbidity and mortality among independent cross-sectional probability samples of the Minneapolis-St. Paul, Minnesota, metropolitan area. Surveys were conducted in 1980-1982, 1985-1987, 1990-1992 and 1995-1997. Diet was among the CVD risk factors measured as part of each survey. In this research, 24-hour dietary recalls collected from MHS participants will be recalculated using an updated food and nutrient database that includes trans-fatty acid values (16:1, 18:1, 18:2, and total). Intake estimates resulting from recalculation will be analyzed to examine temporal trends in trans-fatty acid intake between 1980 and 1997, and to examine the relationship of temporal trends in trans-fatty acid intake to temporal changes in other dietary and non-dietary CHD risk factors and changes in CHD mortality. The MHS data provide a unique opportunity to examine a dietary constituent only recently recognized as a potential risk factor for CHD.