MECHANISMS OF IMMUNOLOGIC TOLERANCE AND ITS BREAKDOWN

描述（改编自申请人的申请）：建立 免疫耐受是免疫学的基本原理之一， 最活跃的研究领域。了解自我的机制 耐受性的非自我辨别及其在自身免疫中的破坏， 开发免疫性疾病治疗新疗法的前沿 疾病，如糖尿病、狼疮和多发性硬化症。目前， 耐受性的转基因模型，使用具有重排的T细胞和B细胞的小鼠 受体和表达肽或抗原， 启动子，为耐受机制提供了新的见解。审查 宽容的命运（例如，无反应性）细胞也被 这类模式的推动。此外，这些模型，以及使用 克隆的T和B细胞系或淋巴瘤，提供了令人兴奋的方法， 了解免疫系统中无反应性与凋亡的信号。 本次会议将讨论免疫耐受的机制及其 自身免疫的崩溃，以及新的疗法，通过促进 基础和临床研究人员在不同领域的互动。将具有 生物技术科学家以及博士后研究员也对此非常感兴趣。

DESCRIPTION (adapted from the applicant s application): The establishment of immunologic tolerance is one of the fundamental tenets of immunology and one of the most active areas of research. Understanding the mechanisms of self- nonself discrimination in tolerance and its breakdown in autoimmunity are at the cutting edge for developing new therapies in the treatment of immunologic diseases, such as diabetes, lupus and multiple sclerosis. Currently, transgenic models for tolerance, using mice with rearranged T- and B-cell receptors and expressing peptides or antigens under the control of different promoters, provide novel insights into tolerance mechanisms. Examination of the fate of tolerant (e.g., anergic) cells in the periphery has also been facilitated by such models. Moreover, these models, as well as the use of cloned T- and B-cell lines or lymphomas, are providing exciting approaches to understanding the signals for anergy versus apoptosis in the immune system. This meeting will address the mechanisms of immunologic tolerance and its breakdown in autoimmunity, as well as novel therapies, by promoting the interaction of basic and clinical researchers in diverse fields. It will be of great interest also to biotech scientists, as well as post-doctoral fellows.