CALCIUM/CALMODULIN SIGNALS & ACTIVATION OF CAM KINASEII

钙调素被认为是最重要的钙信号传感器 转导 当钙调素上的四个钙结合位点 占据，钙调蛋白成为一种多功能激活剂， 大量的关键细胞功能，特别是在神经元中， 中枢神经系统然而，人们对大型 许多钙调蛋白依赖性细胞功能可以被选择性地 控制。 在所提出的实验中，我将定义 钙调素的可用性在空间中调节的机制， 时间和调查的重要性，这种局部钙调素调节 CaM激酶Ⅱ功能。这些研究将在生活中进行 培养的海马神经元。

Calmodulin is thought to be the most important calcium sensor in signal transduction. When the four calcium binding sites on calmodulin are occupies, calmodulin becomes a multifunctional activator that regulates a large number of critical cell functions, particularly in neurons of the central nervous system. However, little is known about how the large number of calmodulin-dependent cell functions can be selectively controlled. In the proposed experiments, I will define the fundamental mechanisms by which calmodulin availability is regulated in space and time and investigate the importance of this local calmodulin regulation for CaM kinaseII function. These studies will be carried out in living cultured hippocampal neurons.