MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS

迈阿密大学这项申请的主要目标是 继续参加合作社的第三个周期 多中心新生儿研究网络。该网络的目标是 目前由12所大学组成的新生儿中心正在调查 治疗和管理策略在护理中的安全性和有效性 新生儿，特别是低出生体重的婴儿。人们希望， 这个已建立的、正在进行的网络将为此类研究工作提供便利 通过提供大量可供研究的母亲和婴儿 以及一支成熟的研究团队，准备实施多个项目 同时。迈阿密大学积极参与了这一活动 过去10年的网络，提供专业知识、领导力和 以合作精神提升网络的目标。分部 新生儿科拥有庞大的、多元化的、多元文化的人群，杰出 临床、实验室和研究设施，以及称职和 敬业的员工。成功参与的历史由来已久 在多中心临床试验和个人研究人员中 启动的项目。之前的主要合作临床试验已经 包括参与产前糖皮质激素的管理 为预防呼吸窘迫综合征(NHLBI)，高频 通风研究(NHLBI)与婴儿健康和发育计划 (罗伯特·伍德·约翰逊，NICHD，妇幼保健，皮尤基金会)。虽然正常 在过去的几年中，新生儿出生人口显著减少。 多年来，对新生儿的特殊护理一直收效甚微 人口。这是由于成功地对复杂、高风险的 母亲以及对非常小的未成熟婴儿的转介增加 来自该地区多个二级单位的转介和来自 加勒比海、中美洲和南美洲。因此，该程序绘制 母亲和婴儿来自一个地区，每个地区有超过40,000次分娩 年。新生儿特别护理中心的工作人员超过250人， 包括全职新生儿呼吸治疗师和新生儿 药剂师，以及护士、执业护士、临床主治医生、 研究员、住院医生和新生儿科医生。有八个董事会通过了认证 和1名具有专业知识的合格新生儿专科医生 心肺生理学、发育医学、血液学、 免疫学和传染病、中枢神经系统及其影响 对胎儿和新生儿的药物滥用。一个非常大的，全面的 指导多学科临床随访和干预计划 由这份意见书的私家侦探。除了它的临床承诺之外 这个项目，在过去的几年里，大学设计和 为这个项目完成了一个大的临床和办公区域。地面是 上个月，一座12层的儿科研究大楼被拆毁 为正在进行的学生分配特定空间的医学校园 这项研究项目的实施，包括临床和 从行政上来说。迈阿密大学已经做出了重大承诺 这一重要的临床网络，并真诚地努力继续 在接下来的5年中进行此协作，试图解决 慢性阻塞性肺疾病诊断和治疗的复杂和重要进展 刚出生的。

The primary objective of this application by the University of Miami is for continued participation in the third cycle of the Cooperative Multicenter Neonatal Research Network. The goal of the network, which is currently made up of 12 university neonatal centers is to investigate the safety and efficacy of treatment and management strategies in the care of newborn infants, particularly those of low-birth-weight. It is hoped that this established, on-going network will facilitate such research efforts by providing large populations of mothers and infants available for study and an established research team ready to implement multiple projects simultaneously. The University of Miami has actively participated in this network for the past 10 years providing expertise, leadership and a cooperative spirit to enhance the network's goals. The Division of Neonatology has a large, diverse, multi-cultural population, outstanding clinical, laboratory and research facilities, as well as competent and dedicated personnel. There is a long history of successful participation in multicenter clinical trials as well as individual investigator initiated projects. Previous major collaborative clinical trials have included participation in the administration of prenatal glucocorticoids to prevent respiratory distress syndrome (NHLBI), the high frequency ventilation study (NHLBI) and the infant health and development program (Robert Wood Johnson, NICHD, MCH, Pew Foundation). Although the normal newborn birth population has decreased significantly over the last several years, there has been little effect on the neonatal special care population. This is due to successful triage of complicated, high-risk mothers as well as increased referrals of very small, immature infants from multiple level II units in the district and additional referrals from the Caribbean, Central and South America. Hence, the program draws mothers and infants from an area encompassing over 40,000 deliveries per year. The staff of the neonatal special care center numbers over 250 and includes full-time neonatal respiratory therapists and neonatal pharmacists, as well as nurses, nurse practitioners, clinical attendings, fellows, residents and neonatologists. There are eight board certified and 1 board eligible neonatologists within the program who have expertise in cardio-pulmonary physiology, developmental medicine, hematology, immunology and infectious disease, central nervous system, and the effects of substance abuse on the fetus and newborn. A very large, comprehensive multidisciplinary clinical follow-up and intervention program is directed by the P.I. of this submission. In addition to its clinical commitment to this project, over the last several years the University has designed and finished a large clinical and office area for this project. Ground was broken within the last month for a 12 story pediatric research tower on the medical campus with specific space allocated to the on-going implementation of this research project, both clinically and administratively. The University of Miami has made a major commitment to this important clinical network and is sincere in its effort to continue this collaboration over the next 5 year cycle, attempting to address complex and important advances in the diagnosis and treatment of the newborn.