ERADIAMR

抗菌素耐药性细菌是21世纪世纪的主要健康挑战之一。仅在2019年，就有近500万人死亡与未能治疗耐药菌引起的感染有关。显然迫切需要找到新的方法来更快速、更有效地检测抗微生物剂耐药性细菌。ERADIAMR项目将开发一种通过观察活细菌振动方式来检测抗菌素耐药性细菌的新方法。事实上，我们最近发现，当细菌用特定的抗生素药物治疗时，它们会以不同的方式振动，这取决于它们对使用中的抗生素是敏感还是耐药。感知这些振动只需要4个小时，因此将使我们能够非常快速地了解需要使用哪种抗生素来治疗感染。相比之下，目前医生可能需要一天以上的时间来决定使用哪种抗生素。在这个项目中，我们将研究通常感染人类的细菌的振动，迫切需要找到最好的抗生素治疗。因此，我们将开发的新技术将允许在未来快速检测和治疗由耐药细菌引起的感染并挽救生命。

Antimicrobial resistant bacteria are one of the major health challenges of the 21st century. In 2019 alone, nearly 5 million deaths were associated with failure to treat infections caused by resistant bacteria. There is a clear and urgent need to find new ways to detect antimicrobial resistant bacteria more rapidly and more effectively. The ERADIAMR project will develop a new way of detecting antimicrobial resistant bacteria by looking at the way live bacteria vibrate. In fact, we have recently discovered that when bacteria are treated with a specific antibiotic drug, they vibrate in a different way depending on whether they are susceptible or resistant to the antibiotic in use. Sensing these vibrations requires only 4 hours and therefore will allow us to understand very quickly which antibiotic needs to be used to cure an infection. In contrast, currently it can take longer than a day for a physician to decide which antibiotic should be used with current standard methods. In this project we will look at the vibrations of bacteria that typically infect humans and against which there is an urgent need to find the best antibiotic treatment. Therefore, the new technology that we will develop will allow in the future to rapidly detect and treat infections due to resistant bacteria and save lives.