课题基金 / 基金详情

SKELETAL MUSCLE ENGERGY CONVERTOR FOR CARDIAC ASSISTANCE

SKELETAL MUSCLE ENGERGY CONVERTOR FOR CARDIAC ASSISTANCE
用于心脏辅助的骨骼肌能量转换器
批准号:
2883273
负责人:
DAVID J FARRAR
金额:
$24.65万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-03-01 至 2001-02-28

项目摘要

项目成果

DAVID J FARRAR的其他基金

相关文献

中文摘要
翻译
描述(改编自申请人摘要):有 对心脏移植替代品的需求未得到满足。 植入式机电循环支持装置显示了一些 承诺,但复杂的系统需要电池和频繁的 充电。这些系统的复杂性可能会降低,并且 通过适当的方法消除电池运输和充电问题 利用骨骼肌力,例如获得专利的方法(美国 专利#5,344,385)。这样做的目的是 项目是继续开发一种生物力学优化的能量 用于以线性收缩为心脏辅助装置供电的转换器 肌肉几何学。这样的线性系统可以提供高达十倍的 肌肉包裹手术的力量。在我们的创新系统中, 插入背阔肌或其他合适的肌肉是 重新连接到一个小活塞上,在肌肉刺激期间,它可以 为各种心脏辅助血泵提供液压动力。这个 该项目的技术优势将在阶段中得到进一步展示 二是通过协同工作对设计的持续发展 骨骼肌能量转换器,以及水力功率的确定 和体内的效率。这项技术不仅具有重要的意义 商业潜力,但也提供了心脏的替代选择 移植的生活质量很高。 建议的商业应用:不可用
英文摘要
DESCRIPTION (Adapted from applicant's abstract): There is an unfulfilled need for alternatives to cardiac transplantation. Implantable electromechanical circulatory support devices show some promise, but are complex systems that require batteries and frequent recharging. The complexity of these systems might be reduced and the battery transport and charging problems eliminated by a suitable means of harnessing skeletal muscle power, such as the patented approach (US Patent #5,344,385) described in this grant. The objective of this project is to continue development of a biomechanically optimized energy converter for powering cardiac assist devices with a linear contracting muscle geometry. Such linear systems can provide up to ten times the power of muscle wrap procedures. In our innovative system, the insertion of the latissimus dorsi muscle, or other suitable muscle, is reattached to a small piston, which during muscle stimulation, can provide hydraulic power to a variety of cardiac assist blood pumps. The technical merit of this project will be further demonstrated in Phase II by collaborative work on the design of the continued development of the skeletal muscle energy converter, and determining hydraulic power and efficiency in vivo. This technology not only has significant commercial potential, but also offers an alternative to cardiac transplantation with a high quality of life. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Sustained skeletal muscle power for cardiac assist devices: implications of metabolic constraints.
心脏辅助装置的持续骨骼肌力量:代谢限制的影响。
DOI: 10.1097/00002480-200109000-00029
发表时间: 2001
期刊: ASAIO journal (American Society for Artificial Internal Organs : 1992)
影响因子: --
作者: [Reichenbach,SH, Egrie,GD, Marinache,SM, Gustafson,KJ, Farrar,DJ, Hill,JD]
通讯作者: Hill,JD
Evaluation of a skeletal muscle energy convertor in a chronic animal model.
慢性动物模型中骨骼肌能量转换器的评估。
DOI: 10.1097/00002480-200007000-00023
发表时间: 2000
期刊: ASAIO journal (American Society for Artificial Internal Organs : 1992)
影响因子: --
作者: [Reichenbach,SH, Gustafson,KJ, Egrie,GD, Weidman,JR, Farrar,DJ, Hill,JD]
通讯作者: Hill,JD
Chronic implantation of a skeletal muscle energy convertor for cardiac assist devices: a preliminary report.
用于心脏辅助装置的骨骼肌能量转换器的长期植入:初步报告。
DOI: 10.1097/00002480-199809000-00091
发表时间: 1998
期刊: ASAIO journal (American Society for Artificial Internal Organs : 1992)
影响因子: --
作者: [Reichenbach,SH, Gustafson,KJ, Khazalpour,KM, Farrar,DJ, Hill,JD]
通讯作者: Hill,JD
SKELETAL MUSCLE ENGERGY CONVERTOR FOR CARDIAC ASSISTANCE
SKELETAL MUSCLE ENERGY CONVERTOR FOR CARDIAC ASSISTANCE
VENTRICULAR SYSTOLIC INTERACTIONS DURING HEART FAILURE
VENTRICULAR SYSTOLIC INTERACTIONS DURING HEART FAILURE