Evaluation of a skeletal muscle energy convertor in a chronic animal model.

Evaluation of a skeletal muscle energy convertor in a chronic animal model.
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慢性动物模型中骨骼肌能量转换器的评估。

DOI:
10.1097/00002480-200007000-00023
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发表时间:
2000
期刊:
ASAIO journal (American Society for Artificial Internal Organs : 1992)
影响因子:
--
通讯作者:
Hill,JD
Hill,JD
中科院分区:
--
文献类型:
--
作者:
Reichenbach,SH;Gustafson,KJ;Egrie,GD;Weidman,JR;Farrar,DJ;Hill,JD

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正在开发一种用于通过将肌肉功转换成液压能来为心脏辅助装置提供动力的装置,其中骨骼肌以线性配置收缩。原型装置被植入山羊体内,以研究装置性能和相关的肌肉力学。经皮液压管路提供了在电调节方案期间控制肌肉负荷和评估肌肉性能的方法。7只山羊的慢性植入持续时间为36至87天。用肌腱环将背阔肌(LDM)附着点重新连接到器械上。胸骨板与接骨螺钉连接,肋骨夹固定器械。实施了一种新的组配式胸骨支架设计,以消除使早期植入物复杂化的接骨板松动。观察到肋骨夹周围广泛的骨重建。肌腱附着显示出足够的初始强度;然而,在5个植入物中,需要努力修复肌腱。观察到器械包封,但器械继续自由循环,未发现与器械的栓系粘连。在某些情况下,囊壁和LDM之间的相互作用似乎限制了LDM的运动。开发长期的动物模型进行能量消耗评估是骨骼肌动力心脏辅助的重要一步。
A device is under development for powering cardiac assist devices with skeletal muscle contracting in a linear configuration by converting muscle work to hydraulic energy. Prototype devices are being implanted in goats to study device performance and associated muscle mechanics. Percutaneous hydraulic lines provide the means to control muscle load and evaluate muscle performance during an electrical conditioning protocol. Chronic implant durations ranged from 36 to 87 days in 7 goats. The latissimus dorsi muscle (LDM) insertion was reconnected to the device with a tendon loop. A sternal plate attached with bone screws, and a rib clamp secured the device. A new modular sternal mount design was implemented to eliminate plate loosening that complicated early implants. Extensive bone remodeling around the rib clamp was observed. The tendon attachment demonstrated sufficient initial strength; however, in five implants, efforts to repair the tendon were required. Device encapsulation was observed, but the device continued to cycle freely and no tethering adhesions to the device were found. Interactions between the capsule wall and LDM seemed to limit LDM movement in some cases. Development of a long-term animal model for energy convertor evaluations is an important step toward skeletal muscle powered cardiac assist.
用于心脏辅助装置的骨骼肌能量转换器的长期植入:初步报告。
DOI: 10.1097/00002480-199809000-00091
发表时间: 1998
期刊: ASAIO journal (American Society for Artificial Internal Organs : 1992)
影响因子: --
作者:
Reichenbach,SH;Gustafson,KJ;Khazalpour,KM;Farrar,DJ;Hill,JD
通讯作者: Hill,JD
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期刊: The Annals of thoracic surgery
影响因子: --
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发表时间: 1996
期刊: The Annals of thoracic surgery
影响因子: --
作者:
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一种永久性假体,用于将原位肌肉收缩转化为液压动力以辅助心脏。
DOI: 10.1152/jappl.1997.82.5.1704
发表时间: 1997
影响因子: 3.3
作者:
D. Trumble;James A. Magovern
通讯作者: James A. Magovern