CHEMOPREVENTION WITH RODENT MODELS OF HEAD & NECK TUMORS

头颈部肿瘤是比较常见的上皮性肿瘤 在人身上。头部和颈部的肿瘤似乎提供了一个特别的 自手术后， 介入治疗肿瘤局部复发率相对 高事实上，以前已经表明，类维生素A可以 显著改变头部肿瘤的复发率， 脖子化学预防分支在这方面的初步尝试 特定区域需要使用DMBA仓鼠颊囊模型。 总的来说，我们发现这个模型对各种各样的 化学预防药因此，我们希望研究另一种模式。 第一个是诱导大鼠舌肿瘤的模型 使用致癌物4 NQO。 正如Gerson口腔病变在 由4-NQO产生的大鼠与人类病变相似， 溃疡和内生性舌病变。的目的 拟议的研究将调查一系列的四种化合物 在4 NQO模型中进行化学预防活性， 在转基因模型中使用单一药剂的初步研究。

Tumors of the head and neck are relatively common epithelial tumors in people. Tumors of the head and neck appear to offer a particularly appealing model for clinical studies since following surgical intervention the rate of local recurrence of tumors is relatively high. In fact it has previously been shown that retinoids can significantly alter the rate of recurrence of tumors of the head and neck. The initial attempts of the Chemoprevention Branch in this specific area entailed the use of the DMBA hamster cheek pouch model. In general we found this model to be unresponsive to a variety of chemopreventives. We wish therefore to examine an alternative model. The first is a model for inducing tumors of the tongue in rats employing the carcinogen 4NQO. As reviewed by Gerson oral lesions in rats produced by 4-NQO are similar to human lesions since manyare ulcerated and endophytic tongue lesions. The objective of the proposed studies will be to investigate a series of four compounds for chemopreventive activity in the 4NQO model and to perform preliminary studies with a single agent in the transgenic model.