VARIOUS CHEMOPREVENTIVE AGENTS EFFECTS

本工作说明的目的是研究 MNU诱导大鼠多种潜在化学预防剂 乳腺肿瘤模型 该模型需要将MNU注入50 一天大的老鼠产生的肿瘤具有许多相同的特性 （组织病理学、内分泌学、对已知治疗的反应和 化学预防剂）是人类疾病的典型。 该模型 将用于检测一些潜在的化学预防剂 包括芳香酶抑制剂、分化剂、特异性 前列腺素合成的抑制剂等。 将进一步研究在这些模型中的有效性， 其生物学和毒理学特性，并进入临床 测试这些初步结果是否有希望。

The objective of this workstatement is to investigate the efficacy of a variety of potential chemopreventive agents in that MNU-induced rat mammary tumor model. This model which entails injection of MNU into 50 day old rats results in tumors with many of the same properties (histopathologic, endocrinologic, response to known therapeutic and chemopreventive agents) that are typical of the human disease. This model will e used to examine a number of potential chemopreventive agents including aromatase inhibitors, differentiating agents, specific inhibitors of prostaglandin synthesis, etc. Agents which are highly effective in these models will be further investigated with respect to their biologic and toxicologic properties and advanced into clinical testing if these initial results appear promising.