FASEB SUMMER CONFERENCE-- FOLATE, B12 AND 1C METABOLISM

申请人的描述（Applicant's Description） 申请资金用于部分支持第八届FASEB夏季研究 叶酸、维生素B12和一碳代谢会议将举行 在美国实验学会联合会的赞助下， 生物学（FASEB）从2000年8月5日至8月10日在斯诺马斯村，科罗拉多。 本次会议为临床科学家提供了一个独特的机会， 科学家，以及那些参与科学政策的人， 正式和非正式互动的学科。 相遇每一个人 去年，过去六次会议已全部订阅和参与， 这次会议将限于210人。 请拨资金用于 允许研究生，居民和博士后研究员，并建立 国家和国际科学家出席会议。 详细 该计划提出，其中包括完善的科学家，以及 刚进入这个领域的年轻科学家 此外，主题还包括 从当前的临床问题到最严重的 复杂的生物化学和生物物理研究。 班 （1）单碳代谢：酶学和调节;（2） 同型半胱氨酸代谢及病理生理学;（3）蛋氨酸代谢： 酶学和调节（4）甲基代谢（5） 叶酸和B12代谢物;（6）叶酸依赖性酶反应作为靶点 （7）叶酸和叶酸拮抗剂;（8）B12 维生素B12的合成与依赖酶;（9）叶酸、维生素B12的遗传性疾病 B12和同型半胱氨酸代谢。 除了正式的介绍外， 计划将辅以海报会议和研讨会。 第一 研讨会将更新各种同型半胱氨酸降低维生素的进展 预防心血管疾病的干预试验。 第二个将 讨论食品叶酸强化作为一项公共政策。 这些提供了许多 非正式讨论的机会，并允许研究生，居民 和博士后研究员，以及建立科学家，有机会 介绍并讨论他们的工作。 最有趣的新研究 将以下列形式向更广泛的受众传播： 一个或多个“国家的最先进的”评论在FASEB杂志。

DESCRIPTION (Applicant's Description) Funds are requested for partial support of the 8th FASEB Summer Research Conference on Folic Acid, Vitamin B12 and One Carbon Metabolism, to be held under the auspices of the Federation of American Societies for Experimental Biology (FASEB) from August 5 - August 10, 2000 at Snowmass Village, Colorado. This conference offers a unique opportunity for clinician scientists, basic scientists, and those involved in science policy from a broad group of disciplines to interact both formally and informally. Meeting every other year, the last six conferences have been fully subscribed and participation at this conference will be limited to 210 individuals. Funds are requested to allow graduate students, residents and postdoctoral fellows, and established national and international scientists to attend the meeting. A detailed program is presented which includes well established scientists as well as junior scientists just entering the field. In addition, topics cover the entire spectrum from current clinical problems to areas of the most sophisticated biochemical and biophysical research. Sessions have been scheduled on (1) One carbon metabolism: Enzymology and regulation; (2) Homocysteine metabolism and pathophysiology; (3) Methionine Metabolism: Enzymology and regulation (4) Methyl group metabolism (5) Translocation of folate and B12 metabolites; (6) Folate-dependent enzyme reactions as targets for chemotherapy; (7) Folates and antifolates in therapeutics; (8) B12 Synthesis and B12-dependent Enzymes; (9) Genetic diseases of folate, vitamin B12 and homocysteine metabolism. In addition to the formal presentations, the program will be complemented with poster sessions and workshops. The first workshop will update progress of the various homocysteine-lowering vitamin intervention trials for cardiovascular disease prevention. The second will discuss food folate fortification as a public policy. These offer many opportunities for informal discussions and allow graduate students, residents and postdoctoral fellows, as well as established scientists, an opportunity to present and discuss their work. The most interesting new research presented at the conference will be disseminated to a much wider audience in the form of one or more "state-of-the-art" reviews in the FASEB Journal.