INTERFACE OF MOLECULAR BIOLOGY AND NUCLEAR MEDICINE

申请人的描述（applicant's description） 这是一个明确的研讨会，将于2000年6月3日星期六举行， 第47届核医学学会年会将于2017年10月27日在纽约举行。 第二天，在圣路易斯，密苏里州。 这一系列研讨会的目的之一是 将核医学界的几位成员聚集在一起， 在他们的研究中利用分子生物学。 我们希望 为与会者提供机会，向这些专家学习如何 分子生物学的工具已经并且可以被应用于改善核生物学。 医学成像和治疗。 第二个目标是继续执行 向核医学专家介绍分子生物学概念 通过提供一些介绍性的演讲，并要求这些演讲者 在符合这一政策的基础上介绍他们的科目。 我们 我相信，这些和其他分子生物学应用的例子， 生物学将是必不可少的核医学专家在不久的 未来 与以往一样，我们认为这次明确的研讨会是 提供这种基本的理解。 具体而言，本次研讨会的目的是使与会者能够 了解：1.与核医学相关的分子生物学基础。 特别是，基因表达和控制的基础知识， 蛋白质合成的重组DNA方法; 2.一种成像方法 通过靶向表达内源性螯合剂的报告蛋白的基因表达 与Tc-99m的弱配合物; 3.另一种成像基因表达的方法 用In-111标记的奥曲肽靶向报告生长抑素受体; 4.利用重组DNA技术制备工程抗体 具有改进的用于用各种放射性同位素成像的性质的构建体; 5.核医学中反义显像的现状及其与肿瘤的关系 适体;和6.利用DNA三链体形成作为定位的手段 放射性碘化DNA与细胞内靶点进行治疗。

DESCRIPTION (Applicant's Description) This is a categorical seminar to be held Saturday, June 3, 2000 prior to the 47th Annual Meeting of the Society of Nuclear Medicine which will commence the following day in St. Louis, MO. One objective of this seminar series is to bring together several members of the nuclear medicine community who are making important use of molecular biology in their research. We hope to provide attendees with an opportunity to learn from these experts on how the tools of molecular biology have been and can be applied to improve nuclear medicine imaging and therapy. A second objective is to continue a policy of introducing molecular biological concepts to the nuclear medicine specialist by providing several introductory presentations and by asking these speakers to introduce their subjects at a basic level consistent with this policy. We believe that these, and other, examples of the applications of molecular biology will be essential for the nuclear medicine specialist in the near future. As before, we view this categorical seminar is one important step in providing this basic understanding. Specifically, the aim of this seminar is to enable the attendees to understand: 1. The basics of molecular biology relevant to nuclear medicine. In particular, the basics of gene expression and control and the basics of recombinant DNA approaches to protein synthesis; 2. One method of imaging gene expression by targeting reporter proteins expressing endogenous chelators with weak complexes of Tc-99m; 3. Another method of imaging gene expression by targeting reporter somatostatin receptors with In-111 labeled octreoscan; 4. The use of recombinant DNA techniques to prepare engineered antibody constructs with improved properties for imaging with various radioisotopes; 5. Current status of antisense imaging in nuclear medicine and its relation to aptamers; and 6. The use of DNA triplex formation as a means of localizing radio iodinated DNA to intracellular targets for therapy.