HOST / GUEST INTERACTIONS IN CATANIONIC VESICLES

描述(摘自摘要)：两亲性分子，如表面活性剂和 磷脂自组装形成复杂的层级结构 包括由球形疏水双层组成的单层囊泡 将内部水室与外部介质分开的贝壳。 这种双层膜由两层表面活性分子(“内层”)组成。 以及具有不同程度的表面活性剂填充度的“外层”小叶)。这 形态为封装、隔离、 和/或“客体”试剂的浓度。尺寸和尺寸的变化 囊泡“宿主”系统的表面电荷有助于设计 量身定做的客人位置和送货车辆。目前的项目建议 继续检查非共价相互作用，这些作用决定了 蒽环类抗生素在细胞膜、脂质体和细胞内的分布 其他膜模型系统。光散射测量与荧光 光谱研究将被用来描述 囊泡尺寸、客体分布和囊泡表面活性物质组成。

DESCRIPTION (from abstract): Amphiphilic molecules such as surfactants and phospholipids self assemble to generate complex hierarchical structures including unilamellar vesicles consisting of spherical hydrophobic bilayer shells that separate an inner aqueous compartment from the external medium. This bilayer consists of a double layer of surfactant molecules (the "inner" and "outer" leaflets) with different degrees of surfactant packing. This morphology provides distinct microenvironments for encapsulation, isolation, and/or concentration of "guest" reagents. Variations of the dimensions and surface charges of the vesicle "host" systems could facilitate the design of tailored guest location and delivery vehicles. The current project proposes to continue the examination of non-covalent interactions that dictate the distribution of anthracycline antibiotics within cell membranes, liposomes, and other membrane model systems. Light scattering measurements and fluorescence spectroscopic studies will be used to characterize the correspondence between vesicle dimensions and guest distribution and vesicle surfactant composition.