MOLECULAR GENETIC ANALYSIS OF THE PRP GENE IN ANIMAL SPECIES SUSCEPTIBLE TO TSES

骡鹿和落基山麋鹿患上慢性消耗性疾病， 属于传染性海绵状脑病 （TSE）。 PrP基因编码区已经在黑尾鹿中进行了分析， 落基山麋鹿。 PrP的氨基酸序列预测值与文献值接近 两个物种之间相同（99.6%），只有一个差异， 密码子226（分别为谷氨酰胺和谷氨酸）。 A多态性 在黑尾鹿PrP中检测到138位密码子（丝氨酸到天冬酰胺）的突变。 基因编码区 进一步调查正在进行中，以确定是否 这种多态性在黑尾鹿对慢性 消耗性疾病分析300个不同形式的 对非人类灵长类动物的TSE显示，恒河猴具有最低的 传输成功率。 对PRNP基因的分析已经 开始阐明遗传因素在易感性中的作用， 恒河猴到TSE。

Mule deer and Rocky Mountain elk develop chronic wasting disease that belongs to the group of transmissible spongiform encephalopathies (TSEs). The PrP gene coding region has been analyzed in mule deer and Rocky Mountain elk. The predicted amino acid sequence of PrP was nearly identical (99.6%) between two species, with only a single difference at codon 226 (glutamine and glutamic acid, respectively). A polymorphism at codon 138 (serine to asparagine) has been detected in mule deer PrP gene coding region. Further investigation is underway to establish if this polymorphism plays a role in susceptibility of mule deer to chronic wasting disease. Analysis of 300 transmissions of different forms of TSEs to nonhuman primates revealed that rhesus monkeys had the lowest rate of successful transmission. Analysis of the PRNP gene has been initiated to elucidate the role of genetic factors in susceptibility of rhesus monkeys to TSE.