PSYCHOPHYSIOLOGICAL EFFECTS OF STIMULANT DRUGS IN CHILDREN

在休息时记录皮肤电活动和心率， 在43名强迫症患者中， 和30名患有破坏性行为障碍的男孩， 在同一周内抽取脑脊液。 偏相关 控制年龄和性别后表明，在强迫症组中，代谢产物 5-羟色胺和多巴胺，但不是去甲肾上腺素， 与皮肤电反应性相关，在 反应时间任务 这在捣乱的男孩身上并没有复制。 促肾上腺皮质激素与皮电呈正相关 整个疗程的活动和心率。 的结果 强迫症受试者表明黑质纹状体多巴胺周转率和 一般来说，中枢5-羟色胺周转会影响皮电活动 确认和扩展药理学研究的结论。 诊断可能会影响这些关系。

Electrodermal activity and heart rate were recorded during rest, simple tones, and a reaction time task in 43 subjects with obsessive compulsive disorder and 30 boys with disruptive behavior disorders who had lumbar cerebrospinal fluid drawn during the same week. Partial correlations controlling for age and sex showed that in the obsessive group metabolites of serotonin and dopamine, but not of norepinephrine, were positively correlated with electrodermal responsivity, most consistently in the reaction time task. This was not replicated in disruptive boys. Adrenocorticotropic hormone was positively related to electrodermal activity and heart rate throughout the session. The results for the obsessive subjects suggest that nigrostriatal dopamine turnover and central serotonin turnover affect electrodermal activity, generally confirming and extending conclusions from pharmacological studies. Diagnosis may affect these relationships.