TRAINING IN MOLECULAR RHEUMATOLOGY AND ORTHOPEDICS

这是一份申请，要求支持继续1994年启动的培训计划，该计划致力于严格培训：(1)在风湿病学或骨科学科中完成临床培训的高度积极的医生；（二）在骨科培训期间选择取得博士学位的医师；(3)刚毕业的博士研究生，从事适用于风湿病或骨科疾病的研究；(4)进入新批准的内科-亚专科研究路径的内科住院医师。该计划提供严密监督的强化实验室经验，强调应用分子生物学，遗传学，细胞生物学和生物化学的最新方法，研究影响结缔组织和肌肉骨骼系统的疾病的病因和发病机制。该培训计划的主要优势是：(1)对影响大部分人口的具有重大公共卫生和社会经济重要性的疾病进行全面和多学科的研究；(2)从最近招募到托马斯·杰斐逊大学的众多成员中选出的高生产力和有成就的调查人员骨干；(3)教师的专业知识和研究兴趣的多样性，以及他们在各种风湿病和肌肉骨骼疾病研究中应用最先进的分子生物学方法；(4)教师长期致力于培养内科科学家和博士。我们建立的项目代表了我们机构之前正在进行的各种培训活动的整合，成为一个统一的项目，高度关注风湿病和肌肉骨骼疾病的病因和发病机制的研究。提供的培训机会有一个统一的目标，即使学员在应用分子生物学、遗传学、细胞生物学和生物化学的最先进方法来研究影响肌肉骨骼系统的广泛疾病方面做好准备。培训活动包括直接监督的实验室研究，辅以正式的课程作业，参加大量预定的讲座和研讨会，参加和展示期刊俱乐部，并在机构和国家会议上展示研究成果。在课程完成后，学员将为获得学术任命和追求医师-科学家或博士的职业生涯做好充分准备，能够在风湿病学和骨科相关领域建立独立的研究项目。

This is an application requesting support to continue a Training Program initiated in 1994 devoted to the rigorous training of: (1) highly motivated physicians who have completed their clinical training in the disciplines of Rheumatology or Orthopedics; (2) physicians who have chosen to obtain a Ph.D. degree during their training in Orthopedics; (3) recently graduated Ph.D.'s committed to conduct research applicable to Rheumatology or Orthopedic diseases; and (4) Internal Medicine Residents entering the newly approved Internal Medicine-Subspecialty Research pathway. The program provides closely supervised intensive laboratory experience emphasizing the application of state of the art methods of Molecular Biology, Genetics, Cell Biology and Biochemistry towards the investigation of the etiology and pathogenesis of diseases affecting the connective tissues and the musculoskeletal system. The major strengths of this Training Program are: (1) the comprehensive and multi-disciplinary approach to the study of disorders of great public health and socioeconomic importance which affect a large segment of the population; (2) the cadre of highly productive and accomplished investigators that have been selected from the numerous members recruited in the recent past to Thomas Jefferson University; (3) the diverse nature of the expertise and research interests of the faculty and their application of the most advanced molecular biological approaches to the study of various rheumatic and musculoskeletal diseases; and (4) the long-term commitment of the faculty to the training of Physician Scientists and Ph.D.'s. The program we established represents a consolidation of various training activities previously ongoing at our institution into a unified program which is highly focused on the study of the etiology and pathogenesis of rheumatic and musculoskeletal diseases. The training opportunities offered have the unifying goal of preparing the trainees in the application of the most advanced methods of Molecular Biology, Genetics, Cell Biology and Biochemistry to the study of a broad spectrum of diseases affecting the musculoskeletal system. The training activities consist of directly supervised laboratory research supplemented by formal course work, attendance to a large number of scheduled lectures and seminars, attendance to and presentation of journal clubs, and presentation of research results at institutional and national meetings. At the completion of the program, the trainees will be extremely well prepared to obtain academic appointments and to pursue careers as Physician- Scientists or as Ph.D.'s capable of establishing independent research programs in areas relevant to Rheumatology and Orthopedics.