Multidisciplinary Training in Molecular and Translational Rheumatology Research

项目摘要/摘要 这是哥伦比亚大学瓦格洛斯医学院重新提交的一份新申请 参加自身免疫性风湿病博士后培训计划的外科医生。该计划的使命是 培训有前途的年轻风湿病学家和早期职业博士研究人员 分子和转化性风湿病科学生涯所需的方法。自身免疫 风湿病(ARDS)是发病率和死亡率的重要原因，发病率似乎是 正在崛起。然而，与此同时，这一数字出现了大幅和渐进的下降。 风湿科医生选择内科医生-科学家的职业。因此，这个新的T32应用程序将解决这个问题 通过确定风湿病学术生涯的高资质候选人并创建创新的 培训环境，满足这些需求，并建立在这项研究的相当大的优势之上 大学。拟议的培训重点围绕三个主要主题，每个主题都反映了ARDS的一个阶段： 1)遗传易感性及其机制；2)临床前自身免疫；3)进展为临床疾病。 我们聘请了一批优秀的风湿病初级导师和外部二级导师。 风湿病，许多已经活跃的合作者，他们跨越多个部门和中心， 涵盖了所有三个研究主题。所有的导师都有充足的资金，其中绝大多数得到了美国国立卫生研究院的资助 并有在调查中成功指导受训人员从事独立职业的记录。 培训期限为两年。受训人员将由风湿病博士后研究员组成，如 以及致力于ARDS研究的博士和医学博士后研究员。资金是 在第1年中请求1个插槽，在第2年和第3年中增加到2个插槽，在第4年中增加到3个插槽 和5.培训计划包括导师的一对一培训，以及必要的讲座和 课程作业，包括选修学位课程作业。培训的主要重点将是学习搭桥 计算科学与风湿病生物学。 这个项目将培养下一代分子和翻译风湿病的研究人员 谁将作为独立的研究人员最终为我国的公共卫生做出重大贡献 调查人员。

Project Summary/Abstract This is a resubmission of a new application from the Columbia University Vagelos College of Physicians and Surgeons for a postdoctoral training program in autoimmune rheumatic diseases. The program’s mission is to train promising young rheumatologists and early career PhD investigators in the methodologies and approaches needed for scientific careers in Molecular and Translational Rheumatology. Autoimmune rheumatic diseases (ARDs) are a significant cause of morbidity and mortality, and incidence rates appear to be rising. Yet at the same time there has been a substantial and progressive decline in the number of rheumatologists choosing physician-scientist careers. Accordingly, this new T32 application will address this need by identifying highly qualified candidates for academic rheumatology careers and creating an innovative training environment that fills these needs and that builds on the considerable strengths of this research University. The proposed training is focused around three major themes, each reflecting a phase of the ARDs: 1) genetic predisposition and mechanisms; 2) pre-clinical autoimmunity; and 3) progression to clinical disease. We have engaged a superb set of primary mentors in Rheumatology and secondary mentors outside Rheumatology, many already active collaborators, who span multiple Departments and Centers and who encompass all three research themes. All of the mentors are well funded, the vast majority with NIH funding and have track records of successfully mentoring trainees to independent careers in investigation. The training period is two years in duration. Trainees will consist of Rheumatology postdoctoral fellows, as well as PhD and MD-PhD postdoctoral fellows who are committed to research in the ARDs. Funding is requested for one slot in Year 1, increasing to two slots in Years 2 and 3, and advancing to 3 slots in years 4 and 5. The training program consists of one-on-one training by the Mentor, as well as required lectures and coursework, and including optional degree coursework. A major focus of training will be on learning to bridge computational science with the biology of rheumatic diseases. This program will prepare the next generation of investigators in molecular and translational rheumatology research who will ultimately make significant contributions to our nation’s public health as independent investigators.