Multidisciplinary Training in Molecular and Translational Rheumatology Research

分子和转化风湿病研究的多学科培训

• 批准号: 10441302
• 负责人: Joan Marie Bathon
• 金额: $ 16.86万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10441302
• 关键词: Molecular; Research; Rheumatology; Training; multidisciplinary

Project Summary/Abstract This is a resubmission of a new application from the Columbia University Vagelos College of Physicians and Surgeons for a postdoctoral training program in autoimmune rheumatic diseases. The program’s mission is to train promising young rheumatologists and early career PhD investigators in the methodologies and approaches needed for scientific careers in Molecular and Translational Rheumatology. Autoimmune rheumatic diseases (ARDs) are a significant cause of morbidity and mortality, and incidence rates appear to be rising. Yet at the same time there has been a substantial and progressive decline in the number of rheumatologists choosing physician-scientist careers. Accordingly, this new T32 application will address this need by identifying highly qualified candidates for academic rheumatology careers and creating an innovative training environment that fills these needs and that builds on the considerable strengths of this research University. The proposed training is focused around three major themes, each reflecting a phase of the ARDs: 1) genetic predisposition and mechanisms; 2) pre-clinical autoimmunity; and 3) progression to clinical disease. We have engaged a superb set of primary mentors in Rheumatology and secondary mentors outside Rheumatology, many already active collaborators, who span multiple Departments and Centers and who encompass all three research themes. All of the mentors are well funded, the vast majority with NIH funding and have track records of successfully mentoring trainees to independent careers in investigation. The training period is two years in duration. Trainees will consist of Rheumatology postdoctoral fellows, as well as PhD and MD-PhD postdoctoral fellows who are committed to research in the ARDs. Funding is requested for one slot in Year 1, increasing to two slots in Years 2 and 3, and advancing to 3 slots in years 4 and 5. The training program consists of one-on-one training by the Mentor, as well as required lectures and coursework, and including optional degree coursework. A major focus of training will be on learning to bridge computational science with the biology of rheumatic diseases. This program will prepare the next generation of investigators in molecular and translational rheumatology research who will ultimately make significant contributions to our nation’s public health as independent investigators.

项目摘要/摘要 这是哥伦比亚大学瓦格洛斯医师学院的新申请的重新提交 自身免疫性疾病的博士后培训计划的外科医生。该计划的使命是 在方法和 分子和转化流变学领域的科学职业所需的方法。自身免疫 风湿病（ARDS）是发病率和死亡率的重要原因，发病率似乎是 上升。然而，与此同时，数量也大幅下降 风湿病学家选择身体科学家职业。据此，该新的T32应用程序将解决此问题 通过确定高素质的学术风湿病学候选人并创造创新的需求 满足这些需求的培训环境，并以这项研究的考虑优势为基础 大学。拟议的培训集中在三个主要主题周围，每个主题都反映了ARDS的阶段： 1）遗传倾向和机制； 2）临床前自身免疫； 3）进展为临床疾病。 我们已经参与了流变学领域的一系列主要导师和外面的次要导师 风湿病学，许多已经活跃的合作者，跨越多个部门和中心，以及 包括所有三个研究主题。所有的导师都有良好的资金，绝大多数拥有NIH资金 并拥有成功心理学员的记录，从事调查的独立职业。 培训期为两年。学员将由流变学博士后研究员组成， 以及致力于研究ARDS的博士学位和MD-PHD博士后研究员。资金是 在第1年要求一个插槽，在第2年和第3年增加到两个插槽，并在4年内前进至3个插槽 和5。培训计划包括导师一对一培训，以及必要的讲座和 课程工作，包括可选学位课程。培训的主要重点是学习桥接 风湿病生物学的计算科学。 该计划将为下一代研究人员准备分子和翻译的风湿病学 研究谁最终将为我们国家的公共卫生做出重大贡献 调查人员。