HIGH RISK DRUG USE & HIV--LEARNING FROM THE NYC EPIDEMIC

纽约市，约有四分之一与注射吸毒有关的艾滋病患者 美国的病例，为研究这种流行病提供了一个独特的机会。 艾滋病毒/艾滋病在高危吸毒者中的传播。NDRI对艾滋病毒进行了研究 和高风险药物使用。目前有9个资助项目 专注于这个主题，因此非常适合容纳一个中心， 研究这种流行病。该提案是针对P30中心，以提供 基础设施，这些已经资助的项目，以增加 这9个项目的个别和协同研究贡献。 建议五个核心小组开展以下活动：（1）提供 数据分析和方法支持，包括跨项目、趋势 和二手数据分析，以及开发新的方法;（2） 在高流行率的纽约市建立基于社区的监测能力 获得关于社区因素的人种学数据， 风险，并监测风险行为和艾滋病毒血清阳性率的趋势， 为NDRI正在进行的项目提供信息;（3）进行战略比较 纽约市的疫情与其他国家和国际 社区，以便能够在社区一级分析影响 血清阳性率、血清发病率和危险行为;（4）培训， 传播职能，包括培训人员， 项目，并向服务提供者传播调查结果，以及（5） 协调整合资源，提高科技含量 互动，支持正在进行的和新的调查，集中共同的 项目职能，并指导新的调查人员。增加的 NDRI研究人员、项目之间的互动、协作和协同作用 这些核心职能所完成的工作， 多学科研究，提高生产力， 研究人员，使解决新的研究问题成为可能， 产生一个综合，并导致增加的影响和利用的 得出项目结论和建议。

New York City, with approximately one-quarter of all IDU-related AIDS cases in the US, provides a unique opportunity for studying the epidemic of HIV/Aids among high-risk drug users. NDRI has conducted research on HIV and high-risk drug use since 1983. It currently has 9 funded projects focusing on this topic, and is thus ideally situated to house a Center for studying this epidemic. This proposal is for a P30 Center, to provide an infrastructure to these already funded projects, to increase the individual and synergistic research contributions made by the 9 projects. Five Cores are proposed to conduct the following activities: (1) provide data analysis and methodological support, including cross-project, trend and secondary data analyses, and development of new methodologies; (2) establish a community-based monitoring capability in a high prevalence NYC community to obtain ethnographic data on community factors influencing risk and to monitor trends in risk behaviors and HIV seroprevalence to inform NDRI's ongoing projects; (3) undertake strategic comparisons between the epidemic in NYC and other national and international communities, to permit community-level analyses of factors influencing seroprevalence, seroincidence, and risk behaviors; (4) training, and dissemination functions, including training personnel for the supported projects, and dissemination of findings to service providers, and (5) coordination and integration of resource to increase scientific interactions, support ongoing and new investigations, centralize common project functions, and mentor new investigators. The increased interaction, collaboration and synergy across NDRI investigators, projects and consultants as accomplished by these core functions, will enhance multidisciplinary research, increase the productivity of the investigators, make it possible to address new research questions, generate a synthesis and lead to increased impact and utilization of the resultant project conclusion and recommendations.