BIOLOGY AND PATHOBIOLOGY OF GI EPITHELIAL CELLS

此申请是为消化系统疾病的竞争性更新 芝加哥大学研究核心中心（DDRCC）。本中心的 主要主题是研究上皮细胞的生物学和病理学， 胃肠道的细胞。 这一复员方案协调委员会将继续是一个 涉及58名研究者（29 正式成员和29个准成员）在临床和基础科学 大学生物科学系各系 芝加哥。本复员方案协调委员会的目标没有改变，是： 消化系统疾病相关的研究，在一个支持性的，综合的， 合作和多学科的方式; 2）加强基本的 消化系统疾病研究者的研究能力; 3） 鼓励研究人员不参与消化系统疾病相关的 研究变得有兴趣追求与此相关的问题 重要的调查领域; 4）制定和实施计划， 培养和建立消化系统疾病的年轻研究人员- 5）促进新研究成果的转移 6）告知其他专业和非专业人员 背景的成就，机遇和进展，消化 疾病相关的研究。 芝加哥大学的DDRCC拥有三个核心实验室（Cell 生物学、分子生物学、生物化学和生物物理学）， 消化系统疾病相关的研究，试点和可行性研究和新的 研究者奖励计划，以促进年轻人和 在消化系统疾病的研究中建立了研究人员， 行政核心监督中心的整体运作。 总的来说，这些目标和组成部分定义了大学的 芝加哥的DDRCC。

This application is for the competitive renewal of the Digestive Disease Research Core Center (DDRCC) at the University of Chicago. This Center's major theme is the study of the biology and pathobiology of epithelial cells of the gastrointestinal tract. This DDRCC will continue to be a multidisciplinary and cooperative endeavor involving 58 investigators (29 full members and 29 associate members) in the clinical and basic science departments of the Division of Biological Sciences at the University of Chicago. The aims of this DDRCC have not changed and are: 1) to foster digestive diseases-related research in a supportive, integrative, collaborative and multidisciplinary manner; 2) to enhance the basic research capabilities of established digestive diseases investigators; 3) to encourage investigators not involved in digestive diseases-related research to become interested in pursuing problems related to this important area of investigation; 4) to develop and implement programs for training and establishment of young investigators in digestive diseases- related research; 5) to facilitate the transfer of new research findings to the clinical area; and 6) to inform others in both professional and lay settings of the accomplishments, opportunities and advances in digestive disease-related research. The DDRCC at the University of Chicago has three core laboratories (Cell Biology, Molecular Biology, and Biochemistry and Biophysics) to foster digestive diseases-related research, Pilot and Feasibility Studies and New Investigator Award programs to foster participation of younger and established investigators in research related to digestive diseases and an Administrative Core to oversee the operation of the Center as a whole. Taken together, these objectives and components define the University of Chicago's DDRCC.