NOVEL CELLULOSE COPOLYMERS FOR BIOMEDICAL APPLICATIONS

我们建议开发新的生物相容性生物材料用于生物医学用途，特别是用于制备分离装置。新的生物材料可以很容易地衍生出高产量，具有成本效益的专有工艺，该工艺还允许制备一系列不同的组合物。初步研究结果表明，这种新型生物材料是一种很有前途的膜材料。建议的商业应用：由于血膜相互作用的有害后果，血液透析患者仍然存在显著的发病率和死亡率。新型有效的血液透析膜将成为该领域的一个重要里程碑。可用于全血的免疫吸附剂的发展将为体外免疫吸附程序的重大改进提供潜力。与传统的色谱介质相比，这些血液相容基质可以在不需要分离血细胞和血浆的前提下使用。

We are proposing the development of new biocompatible biomaterials for biomedical uses and specifically for the preparation of separation devices. The new biomaterials can be readily derived with a high yielding, cost-effective proprietary process that also permits the preparation of a range of different compositions. Preliminary data from pilot studies indicate that the new biomaterials constitute promising membrane materials. PROPOSED COMMERCIAL APPLICATIONS: Significant morbidity and mortality remain in hemodialysis patients due to the deleterious consequences of blood-membrane interactions. New efficacious hemodialysis membranes would constitute a major milestone in this field. The development of immunoadsorbents usable with whole blood should offer the potential for making significant improvements in extracorporeal immunoadsorption procedures. In contrast to traditional chromatographic media, these hemocompatible matrices could be used without requiring the previous step of the separation of blood cells and plasma.