CHEMISTRY OF ARTHROPOD SECRETIONS

昆虫和其他节肢动物占所有描述的一半以上 地球上的物种。有些是重要的疾病媒介(即采采氏病毒 苍蝇、按蚊、三叶虫、扁虱……)，而许多 另一些则发展成农业、森林和家庭害虫。 化学在节肢动物系统学优势中起着关键作用 地球；它是昆虫与植物相互作用的基础， 它们与动物宿主和捕食者的相似之处。酋长 这个项目的目标是阐明这些现象背后的化学原理。 互动。 昆虫和植物已经共同进化了数亿年 这些基团之间的化学关系是丰富的 多种多样。我们的工作也将扩展到工厂，在这些情况下 植物毒素作为昆虫防御化合物的利用 信息素前体似乎很重要。在这些情况下， 昆虫物种依赖植物作为防御的来源 化合物、信息素或其前体、天然产物 将对相关植物物种的化学进行研究。 具有生物活性的新型昆虫衍生化合物的合成 活动将是这一计划的一个重要方面。这是一个 节肢动物化学研究的基本方面，因为合成服务于 不仅要确认结构和立体化学，而且还要确认供应 生物检测所需的足够数量的材料。总体目标 这一计划的主要内容是：(1)增加我们对自然的认识 化学防御和通信，(2)为新的 可能适用于病媒生物的虫害防治技术 其他害虫，以及(3)发现可能有助于 药物和/或农用化学品开发。

Insects and other arthropods make up over half of all the described species on earth. Some are important as disease vectors (i.e., tsetse fly, anopheles mosquitoes, triatomine bugs, ticks ...), while many others have developed into agricultural, forest, and household pests. Chemistry plays a key role in the phyletic dominance of arthropods on earth; it is the basis for the interactions of insects with plants, with their conspecifics, with animal hosts, and with predators. The chief goal of this project is to elucidate the chemistry underlying these interactions. Insects and plants have been co-evolving for hundreds of millions of years, and the chemical relationships between these groups are rich and varied. Our work will also extend to plants in those instances where the utilization of plants toxins as insect defensive compounds and pheromone precursors seem to be important. In those instances where an insect species is dependent on plants as a source of defensive compounds, pheromones, or their precursors, the natural products chemistry of the relevant plant species will be studied. The synthesis of new insect-derived compounds showing biological activity will be an important facet of this program. This is an essential aspect of arthropod chemical research, since synthesis serves not only to confirm" structures and stereochemistry, but also supplies material in sufficient quantity for bioassays. The overall objectives of this program are: (1) to increase our understanding of natural chemical defense and communication, (2) to provide the basis for new insect control techniques which may be applicable to disease vectors of other pests, and (3) to discover new chemistry which may be useful in drug and/or agrochemical development.