Discovering how a novel anti-malarial drug series rapidly kills parasites

我们开发了一套新的高效抗疟疾药物，但我们不知道它们是如何起作用的。确定这些化合物如何起作用对于提高它们的有效性和安全性非常重要。我们将通过使用一些尖端的方法来发现这些药物是如何杀死寄生虫的，这些方法也可能有助于发现其他药物的工作原理。所产生的数据将沿着药物开发管道推进这些化合物，这些管道迫切需要不断提供新的抗疟药物。

We have developed a new set of highly potent anti-malarial drugs but we do not know how they work. Identifying how these compounds work is important for improving their effectiveness and safety. We will discover how these drugs kill parasites by using a number of cutting edge methods that could also be useful for discovering how other drugs work. Data generated will progress these compounds along the drug development pipeline which urgently needs a constant supply of new antimalarials.