RETENTION OF BONE MARROW DONORS IN A NATIONAL REGISTRY

描述：随着骨髓移植成为首选之一 对危及生命的血液疾病的治疗，越来越多的 患者必须从无关的捐赠者那里寻求相容的骨髓。低谷 找到良好的患者和供者骨髓匹配的可能性意味着 三分之一到三分之二的病人从未找到过完美的捐赠者 相容的骨髓。此外，一旦志愿者被确定为 对于一个患者来说，30%到40%的人要么不愿意要么 医学上无法真正捐献骨髓。因此，志愿者自然减员 极大地加剧了在查找 合适的捐赠者候选人。 尽管维护一个庞大的、不相关的 志愿捐赠者候选人，没有系统地研究影响 成功地留住这样的志愿者是存在的。建议进行的研究是 旨在确定影响国家骨髓捐赠者计划的因素 (NMDP)成功保留骨髓志愿者。特别是，这一点 研究将考察志愿者特征和捐赠者之间的关系 在两个关键时期志愿者心理结果的中心因素 血液检测过程中的各个阶段和志愿者的献血中心率 在这些阶段进行合作。 将收集纵向和横断面调查数据 在2600名潜在的骨髓捐赠者中，他们面临着两个关键决定之一 献血过程中的要点(DR血型鉴定， CT血型测定)，以及100个NMDP捐赠者中心的工作人员。这些 数据将使调查人员能够(A)描述分布和 供体中心结构特征与供体功能的相互关系 各中心用来招募和保留志愿者的战略，(B) 确定哪些捐赠者中心因素(结构性和战术性)和 志愿者背景特征最能预测积极 志愿者在以后打字阶段的特定心理结果，以及 检查和修订个别志愿者特定结果的模型，并 合计跨中心保留率。研究结果将更好地促进 了解捐助者管理组织的特点，即 是成功保留骨髓志愿者的关键，通知 修订医疗志愿服务的概念模型，并指导未来 努力确保所有活体器官捐赠的捐赠者。

DESCRIPTION: As bone marrow transplantation becomes one of the preferred treatments for life-threatening diseases of the blood, increasing numbers of patients must seek compatible marrow from unrelated donors. The low probability of finding a good patient-donor marrow match means that between one- to two-thirds of ill patients never locate a donor with perfectly compatible marrow. Furthermore, once volunteers are identified as a preliminary match for a patient, 30 to 40 percent are either unwilling or medically unable to actually donate marrow. Thus, volunteer attrition contributes significantly to the problems already inherent in finding a suitable donor candidate. Despite the critical importance of maintaining a large registry of unrelated volunteer donor candidates, no systematic studies of factors affecting the successful retention of such volunteers exists. The study proposed is designed to identify factors that affect the National Marrow Donor Program's (NMDP) success in retention of bone marrow volunteers. In particular, this study will examine the relationship of volunteer characteristics and donor center factors to volunteer psychological outcomes during two critical stages in the blood testing process and to donor center rates of volunteer cooperation at these stages. Longitudinal and cross-sectional survey data will be gathered from a total of 2,600 potential marrow donors who are at one of two critical decision points in the process leading to donation (DR-blood-typing, CT-blood-typing), and from personnel at the 100 NMDP donor centers. These data will allow the investigators to (a) describe the distribution and interrelationships between donor center structural characteristics and the strategies centers utilize for volunteer recruitment and retention, (b) determine which donor center factors (both structural and tactical) and volunteer background characteristics best predict positive volunteer-specific psychological outcomes at later typing stages, and examine and revise models of individual volunteer-specific outcomes and aggregate across-center retention rates. Study findings will promote better understanding of the donor management organizational characteristics that are central to successful retention of marrow volunteers, inform the revision of conceptual models of medical volunteerism, and guide future efforts to secure donors across the full range of living-organ donation.