METABOLIC PREDICTORS AND MARKERS OF CHILDHOOD OBESITY

描述：该项目的重点是早期代谢的识别 精神障碍与青少年肥胖的发生有关。这个 研究人员建议确定高胰岛素血症或胰岛素 耐药性是“高风险”的主要缺陷。 肥胖父母的青春期前儿童与低风险瘦儿童的比较 非肥胖父母的青春期前儿童在发育之前 肥胖。申请人将使用高血糖钳夹的改进型 量化两组的胰岛素分泌，并独立评估 肠道因素对β细胞对高血糖反应的影响； 她将尝试确定瘦素水平和 青少年肥胖的高胰岛素血症；以及评估 儿茶酚胺缺陷诱导的脂解刺激可能有助于 肥胖儿童的体重进一步增加。为了解决这些问题， 研究人员将利用同位素输注和微透析技术。 观察到的代谢缺陷将与脂肪的变化有关。 通过MRI评估其分布情况。长期目标是生成以下数据 将导致制定新的预防和预防战略 青少年肥胖的治疗。

DESCRIPTION: This project focuses on the identification of early metabolic disturbances implicated in the genesis of juvenile obesity. The investigator propose to determine whether hyperinsulinemia or insulin resistance is the primary defect that is present in "high-risk" preadolescent children of obese parents compared to low risk lean preadolescent children of nonobese parents prior to the development of obesity. The applicant will use a modification of the hyperglycemic clamp to quantify insulin secretion in the two groups and to independently assess the influence of gut factors on the betas cell response to hyperglycemia; and she will attempt to ascertain the relationship between leptin levels and the hyperinsulinemia of juvenile obesity; as well as assess whether defective catecholamine induced stimulation of lipolysis might contribute to further weight gain in obese children. To address these issues the investigator will utilize isotopic infusions and microdialysis techniques. The observed metabolic defects will be related to alterations in fat distribution assessed by MRI. The long-term goal is to generate data that will lead to the development of new strategies for the prevention and treatment of juvenile obesity.