IMPROVED STEREOTAXIC INSTRUMENTATION AND METHODOLOGIES

描述(研究人员摘要)：实验中的许多程序 神经科学依赖于准确和精确的手术途径 大脑中的特定结构，参照已知的地标 头骨和有关脑结构的三维信息 在立体定位地图集上发表。 目前的立体定位工具与日期相比几乎没有变化。 它的原始设计，大约35年前。在此期间， 机床行业在精度和可靠性方面取得了巨大的进步 基本机械机构的精度。 本项目的目的是确定准确度和精密度 这可能是通过立体定位仪获得的 完全采用现代机床原理重新设计。这是一项新的 设计包括精密的面板，它提供了可靠的 平面基准。第二，将开发一种新的通用机械手 使用精确的线性刻度和具有分辨率的数字读数 1微米。最后，自动分度刀架将允许 用户可互换定心示波器、钻头和电极座 一个共同的垂直轴。这一工具有望改善 立体定向手术的精确度提高了5到20倍；这些 结果将由一个独立的校准实验室进行验证 由NIST认证。 建议的商业应用：不可用

DESCRIPTION (Investigator's Abstract): Many procedures in experimental neuroscience depend upon accurate and precise surgical access to specific structures in the brain, in reference to known landmarks on the skull and three-dimensional information about brain structures as published in stereotaxic atlases. The current stereotaxic instrument has seen little change from the date of its original design, about 35 years ago. In the meantime, the machine tool industry has seen dramatic advances in the accuracy and precision of basic mechanical mechanisms. The purpose of this project is to determine the accuracy and precision that might be obtained with a stereotaxic instrument that has been completely re-designed using modern machine tool principles. This new design includes a precision surface plate which provides a reliable planar datum. Second, a new universal manipulator will be developed using precision linear scales and digital readouts with a resolution of 1 micron. Finally, an automatic indexing tool holder will allow the user to interchange centering scopes, drills, and electrode holders on a common vertical axis. This instrument is expected to improve the accuracy of stereotaxic surgery by a factor of 5- to 20-fold; these results will be verified by an independent calibration laboratory accredited by the NIST. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE