CANCER IN CHILDREN

这项建议的长远目标是进一步改善 通过参与儿童癌症的治疗 范德比尔特大学儿童医学院的研究人员 癌症组织(CCS)。来自美国的多学科调查团队 范德比尔特正在与来自其他国家的可比团队共享资源 研究该病的生物学、治疗和流行病学的机构 儿童时期的癌症。 具体目标可以用范德比尔特的贡献来概括 为集团的科学努力和行政领导做出贡献。这些 包括以下内容： 1.通过参与疾病战略小组，建立 研究重点和制定治疗研究的新战略 急性淋巴细胞白血病，霍奇金氏病，神经母细胞瘤， 骨肉瘤和脑瘤。 2.通过担任研究委员会主席，在 调查处理的发展、进行、分析和报告 治疗急性淋巴细胞白血病、神经母细胞瘤和脑瘤。 3.通过作为研究委员会成员参与，协助 进行与治疗ALL有关的研究，霍奇金病 疾病、星形细胞瘤和脑干肿瘤。 4.在研究的发展和解释方面提供领导 评估治疗后的发育和神经心理后遗症 为所有人提供治疗。 5.通过委员会参与，为发展和促进 研究药物的分析。 6.通过参与 执行委员会、干事委员会和附属活动 督导委员会。 此外，调查人员将继续争取 范德比尔特患者在CCG方面的研究方案，以便于 迅速开展并及时完成小组研究。

The long-range objective of this proposal is further improvement in the treatment of cancer in children through the participation of investigators at the Vanderbilt University School of Medicine in Children Cancer Group (CCS). The multi-disciplinary team of investigators from Vanderbilt are pooling resources with comparable teams from other institutions to investigate the biology, treatment, and epidemiology of the childhood cancers. Specific aims can be summarized in terms of Vanderbilt's contributions to the Group's scientific endeavors and administrative leadership. These include the following: 1. Through participation in disease-specific Strategy Groups, establish research priorities and develop new strategies for therapeutic studies of acute lymphocytic leukemia (ALL), Hodgkin's disease, neuroblastoma, bone sarcomas, and brain tumors. 2. Through Study Committee chairmanships, provide leadership in the development, conduct, analysis, and reporting of investigation dealing with the treatment of ALL, neuroblastoma, and brain tumors. 3. Through participation as Study Committee members, assist in the conduct of studies concerned with the treatment of ALL, Hodgkin's disease, astrocytoma, and brain stem tumors. 4. Provide leadership in the development and interpretation of studies that assess the developmental and neuropsychologic sequelae of curative therapy for ALL. 5. Through committee participation, contribute to the development and analyses of investigational drugs. 6. Provide administrative leadership through participation on the Executive Committee, the Officers Committee, and the Affiliate Activities Steering Committee. In addition, investigators will continue to enlist the participation of Vanderbilt patients in CCG research protocols so as to facilitate the expeditious conduct and timely conclusion of Group studies.