HETEROGENEITY OF SCHIZOPHRENIA

描述（改编自研究者摘要）：精神分裂症是 这是世界上尚未解决的主要公共卫生问题之一。 这是一个 相对常见的，慢性的，使人衰弱的疾病的可变表达。 对精神分裂症的病因知之甚少，但有令人信服的 证据表明遗传因素在病因学中起一定作用， 精神分裂症 然而，其机制尚不清楚。 大多数研究者 相信精神分裂症的病因是多样的 这项研究的长期目标是确定相关的基因 对这种复杂疾病的易感性 完成这项工作的方法是 分子遗传学方法 连锁分析与连锁不平衡 研究使用高度多态性微卫星标记在一个独特的 基因同质社区（德系犹太人）将进行。 该建议的具体目标如下：1）招聘和 评估了150名被诊断为德系犹太人的样本， 患有精神分裂症或情感障碍（抑郁型）， 父母愿意参加（三人小组）。 预计 在本研究开始之前将确定50个这样的三人组， 从其他资金来源，使总的三个样本将 由200名德系犹太病人和他们的父母组成 DNA将 分离和淋巴细胞将被分离，冷冻和储存; 2）招募 并评估了100个德系犹太家庭的独立样本， 受影响的兄弟姐妹和至少一名父母愿意参加。 病毒 来自受影响同胞的转化淋巴母细胞系及其 将获得100个同胞对家庭中的父母以及来自 直接提取; 3）对高度多态性的微卫星标记进行分型 在先前在其他人群中鉴定的感兴趣区域中， 三人组样本和同胞对样本，以及完成全基因组 在三人组样本和同胞对样本中扫描以检测新的 易感位点; 4）随访家庭，以维持当前受影响 5）将这一独特的临床资源提供给其他人 研究人员正在努力实现这一目标。

DESCRIPTION (Adapted from the Investigator's Abstract): Schizophrenia is one of the world's major unsolved public health problems. It is a relatively common, chronic, debilitating disease of variable expression. Little is known about the causes of schizophrenia but there is convincing evidence that genetic factors play some role in the etiology of schizophrenia. However, the mechanism is not known. Most investigators believe schizophrenia is etiologically heterogeneous. The long term objective of this study is to identify the genes associated with susceptibility to this complex disease. This will be achieved through molecular genetic approaches. Linkage analysis and linkage disequilibrium studies using highly polymorphic microsatellite markers in a unique genetically homogeneous community (Ashkenazi Jews) will be conducted. The specific aims of the proposal are as follows: 1) to recruit and evaluate a sample of 150 Ashkenazi Jewish patients who are diagnosed as having either schizophrenia or schizoaffective disorder (depressed type) and whose parents are willing to participate (trio panel). It is anticipated that 50 such trios will be identified prior to the beginning of this study, from other sources of funding so that the total trio sample will be comprised of 200 Ashkenazi Jewish patients and their parents. DNA will be isolated and lymphocytes will be isolated, frozen and stored; 2) to recruit and evaluate an independent sample of 100 Ashkenazi Jewish families with affected siblings and at least one parent willing to participate. Virus transformed lymphoblastoid cell lines from the affected siblings and their parents in the 100 sib-pair families will be obtained as well as DNA from direct extraction; 3) to genotype highly polymorphic microsatellite markers in regions of interest previously identified in other populations in both the trio sample and the sib-pair sample, as well as to complete genome-wide scans in both the trio sample and the sib-pair sample to detect new susceptibility loci; 4) to follow-up families to maintain current affected status; and 5) to make this unique clinical resource available to other investigators pursuing this goal.