NIR TUNABLE LASER TISSUE WELDING

描述(改编自申请者摘要)：申请者提出一个 旨在开发紧凑型、便携式近红外的两阶段研究计划 用于组织焊接和更好开发的(NIR)可调谐固体激光器 了解激光组织融合的机理。《公约》的具体目标 建议的研究将是：(1)发展近红外可调谐固体激光器，以 进行激光组织焊接；以及(2)激光组织焊接的研究 可调谐激光在动物皮肤和内部组织中的作用 波长、平均功率、脉冲持续时间、峰值功率、穿透深度和 组织光学特性对融合过程的疗效影响。这个 研究将集中在开发和测试紧凑、便携的近红外 基于众所周知的激光晶体铬镁橄榄石的可调谐固体激光器， Cr：Ca2GeO4和一种有前途的新晶体Cr：LiInGeO4填补了1300左右的空位 NM，为组织焊接发展更好的了解激光组织 融合机制。激光开发工作将提供紧凑和 用于临床组织焊接的具有最佳特性的可靠激光器 申请。

DESCRIPTION (Adapted from Applicant's Abstract): The applicants proposed a two-phase research program aimed at developing compact, portable near-infrared (NIR)-tunable solid-state lasers for tissue welding and developing better understanding of the laser tissue fusion mechanism. The specific aims of the proposed research will be: (1) development of NIR-tunable solid-state lasers to carry out laser tissue welding; and (2) study of the laser tissue welding using tunable lasers in animal skin and internal tissues to determine the effect of wavelength, average power, pulse duration, peak power, penetration depth, and tissue optical characteristics on the efficacy of the fusion process. The research will be focused on developing and testing compact, portable NIR tunable solid-state lasers based on well known laser crystals cr:forsterite, Cr:Ca2GeO4 and a new promising crystal Cr:LiInGeO4 filling the void around 1300 nm, for tissue welding developing better understanding of the laser tissue fusion mechanism. The laser-development effort will provide compact and reliable lasers with optimal characteristics for clinical tissue welding applications.