CORE--CELL AND TISSUE BANK

华盛顿大学ADRC核心E：细胞和组织银行历史上是阿尔茨海默病和其他神经退行性疾病的最古老的储存库，包括家族性和零星的。该中心保存低温保存的淋巴母细胞系、淋巴细胞、成纤维细胞、血浆，以及用于分子和生化实验和分析的活组织和尸检皮肤样本。CORE的目标是：1.获取、扩增和冷冻保存各种类型的细胞，并冷冻来自家族性和散发性阿尔茨海默病(AD)患者的血浆。我们还将从其他退行性疾病患者那里获取和保存细胞、组织和/或细胞系，并进行适当的控制。我们将利用AD相关基因/蛋白的转基因或敲除的细胞和动物模型产生的细胞系。2.应调查人员的要求，将储存的细胞系或菌株分发给ADRC，并在与ADRC执行委员会共同批准后，通过材料转移机制分发给华盛顿大学和其他机构的调查人员。

The University of Washington ADRC Core E: Cell and Tissue Bank is historically the oldest repository for Alzheimer Disease and other neurodegenerative disorders, familial and sporadic. The Core maintains cryogenically preserved lymphoblastoid cell lines, lymphocytes, fibroblasts, plasma, as well as biopsy and autopsy skin specimens for molecular and biochemical experiments and assays. The aims of the Core are: 1. Acquire, expand and cryopreserve various cell types and to freeze plasma derived from patients with familial and sporadic Alzheimer's disease (AD). We will also acquire and preserve cells, tissues, and/or cell lines from patients with other degenerative disorders, and appropriate controls. We will bank cell lines generated from cell and animal models that utilize transgenes or knockouts of AD-associated genes/proteins. 2. Distribute stored cell lines or strains upon request by investigators with in the ADRC and, upon approval in concurrence with the ADRC Executive committee, to investigators at the University of Washington and other institutions via a Materials Transfer mechanism.