Core--Ovarian cancer clinical network

描述：(申请人描述)在最基本的分子水平上了解卵巢癌的潜力对科学界提出了一个挑战，即应用新的和正在开发的技术来促进我们对这种致命疾病的了解。缺乏的是前瞻性地跟踪足够大的卵巢癌患者或有卵巢癌家族风险的女性来明确解决这些问题的机会。《联合国卵巢癌公约》建议建立卵巢癌临床网络核心，这是一个以研究为基础的基础设施，以促进转化性研究的开展，并将新的预防、筛查和治疗策略转化为临床实践。这一核心项目代表了联合国儿童基金会、Fox Chase Network、库珀医疗中心、坦普尔大学、新泽西癌症研究所、好时医疗中心和宾夕法尼亚大学的合作伙伴关系，并为广泛的种族、社会经济和农村/城市人口提供服务。在1600多个高危乳腺癌家庭的既定基础设施的基础上，利用核心设施的综合资源，将汇集一个或多个卵巢癌病例的组织病理学记录的家庭队列。将收集有关医疗、生殖、家庭和生活方式因素的广泛信息。所有参与者的血液样本都将被采集。将向受影响的个人以及为预防而接受卵巢切除术的未受影响的家庭成员索取卵巢组织样本。该核心将设计、开发和支持一个全面的信息管理系统，以确保准确的数据输入和维护，并满足孢子调查人员的需要。咨询和筛查方案将标准化并分发给卫生保健专业人员。该设施将建立在福克斯大通正在进行的开创性工作的基础上，以满足高危家庭的需求，并将扩大这些努力，以促进多学科研究项目。一个动态的卵巢癌研究数据库的创建提供了一个独特的机会来解决多学科的研究问题，并将基因革命产生的关于卵巢癌的知识带给社区。

DESCRIPTION: (Applicant's Description) The potential to understand ovarian cancer at the most basic molecular level poses a challenge to the scientific community to apply the new and developing technologies to advance our understanding of this deadly disease. What has been lacking is the opportunity to prospectively follow a sufficiently large cohort of women with ovarian cancer or with a familial risk for ovarian cancer to definitively address these questions. The FCCC proposes the establishment of The Ovarian Cancer Clinical Network Core, a research-based infrastructure to facilitate the conduct of translational research and to transfer novel prevention, screening and treatment strategies into clinical practice. This core represents a partnership of FCCC, the Fox Chase Network, Cooper Medical Center, Temple University, the Cancer Institute of new Jersey, Hershey Medical Center, and the University of Pennsylvania and provides access to a wide spectrum of ethnic, socioeconomic and rural/urban populations. Building upon an established infrastructure of over 1600 high risk breast cancer families and using the combined resources of the core facility, a cohort of families with histopathologic documentation of one or more cases of ovarian cancer will be assembled. Extensive information on medical, reproductive, family and lifestyle factors will be collected. Blood samples will be collected from all participants. Ovarian tissue specimens will be requested from affected individuals as well as those unaffected family members undergoing oophorectomy for prophylaxis. The core will design, develop, and support a comprehensive information management system to ensure accurate data entry and maintenance and to serve the needs of the SPORE investigators. Counseling and screening protocols will be standardized and disseminated to health care professionals. This facility will build upon the seminal work underway at Fox Chase to serve the needs of high-risk families and will expand these efforts to foster multidisciplinary research projects. The creation of a dynamic ovarian cancer research database provides a unique opportunity to address multidisciplinary research questions and to bring the knowledge about ovarian cancer generated by the genetic revolution to the community.