ECHOCARDIOGRAPHY WORKSTATION FOR ANIMAL RESEARCH

一组多学科研究人员正在申请购买超声成像系统（Acuson Sequoia [型号C256]）的资金，以获得小动物模型的超声心动图。超声心动图或超声成像是一种原位测量心脏解剖和功能的无创方法。总的来说，但与单独的国立卫生研究院支持的研究计划，这个多学科小组将使用大鼠和小鼠转基因模型来检查心脏结构和功能的变化，这些变化与正常以及病理性心血管疾病有关。 将使用M模式定向、二维定向和脉冲波多普勒超声心动图记录来获得心脏解剖结构和功能的信息。 总共有8个主要用户将使用超声心动图系统。 这样一台机器和中心位置（生物资源实验室）的可用性将大大提高参与者的研究生产力。 此外，由于能够在一只动物中进行连续测量，因此根据方案处死的动物数量将减少。大约60%的仪器时间将用于Piano（PI），Buttrick（PI）和Solaro（PI）博士的研究，他们都是现有NIH赠款的主要研究者。 Geenen、Hickson、Arteaga、Varga和Schwertz博士将使用剩余的40%超声心动图成像系统时间。 超声心动图工作站将在儿科心脏病专家Peter Varga博士和Taylor Bennet的指导下运行。 生物资源实验室将在Taylor Bennet博士的指导下负责长期维护。 班纳特署长已委任一个咨询委员会，以制定业务准则和使用费。 总之，伊利诺伊大学芝加哥分校没有可用于动物研究的具有高频换能器的超声心动图机。 一组多学科的研究人员将使用这个系统只在他们的大鼠和小鼠模型的小动物研究。

A group of multidisciplinary researchers are requesting funds for the acquisition of an ultrasound imaging system (Acuson Sequoia [model C256]) to obtain echocardiograms in small animal models. Echocardiography or ultrasound imaging is a noninvasive method for the in situ measurement of cardiac anatomy and function. Collectively, but with separate National Institutes of Health supported research programs, this multidisciplinary group will use rat and murine transgenic models to examine changes in cardiac structure and function that are associated with normal, as well as pathological cardiovascular conditions. M-mode directed, two-dimensional directed and pulse wave Doppler echocardiographic recordings will be used to obtain information on cardiac anatomy and function. Altogether, eight major users will be utilizing the echocardiography system. The availability of such a machine and central location (Biological Resource Laboratory) will greatly enhance the research productivity of the participants in this grant proposal. In addition, because of the ability to make serial measurements in one animal, the number of sacrificed animals per protocol will decrease. Approximately 60 percent of the instrument time will be devoted to the research of Drs. Piano (PI), Buttrick (PI) and Solaro (PI), all of whom are primary investigators on existing NIH grants. The remaining 40 percent of the echocardiography imaging system time will be utilized by Drs. Geenen, Hickson, Arteaga, Varga, and Schwertz. The echocardiography workstation will be operated under the direction of Drs. Peter Varga, pediatric cardiologist, and Taylor Bennet. Long term maintenance will be the responsibility of the Biologic Resources Laboratory under the direction of Dr. Taylor Bennet. Director Bennet has appointed an advisory committee to set operation guidelines and user fees. In conclusion, the University of Illinois at Chicago has no echocardiography machine with a high frequency transducer available for animal research. A group of multidisciplinary researchers will use this system only for small animal research in their rat and murine models.