INTEGRATED XRAY IMAGE PLATE DETECTOR SYSTEM

我们正在申请资金购买最先进的x射线数据收集仪器，包括成像板探测器，旋转阳极x射线发生器以及相关的光学和冷却组件。学院目前使用的多线仪器已有近10年的历史，比大多数学术和工业研究实验室现有的最先进设备落后了一代。因此，在一系列令人兴奋和重要的结构即将得到解决的时候，与我们的同事和竞争对手相比，我们处于严重的劣势。这些被要求的组成部分对医学院结构生物学的持续活力和发展至关重要。所提出的仪器将缓解由于医学院庞大的结构社区造成的数据收集瓶颈。该探测器的空间分辨率、整体效率和增强的立体角将使其能够更快、更有效地收集x射线衍射数据，并提高统计精度。这些特征将直接影响我们解决新结构的能力，并将允许高分辨率的改进，这对理解化学和生物学至关重要。提议的探测器系统将补充学院的NIH资助的研究资源位于布鲁克海文国家实验室，并将允许这些设施的最佳使用。

We are requesting funds to purchase state of the art x-ray data collection instrumentation, including an image plate detector, rotating anode x-ray generator and associated optics and cooling components. The multi-wire instrumentation currently at the College is nearing 10 years old and is a generation behind existing state of the art facilities which are to be found at most academic and industrial research laboratories. We are thus at a severe disadvantage with respect to our colleagues and competitors at a time when a series of exciting and important structures are about to be solved. These requested components are essential to the continued vigor and development of structural biology at the College of Medicine. The proposed instrumentation will relieve a bottleneck in data collection which is caused by the large structural community at the College of Medicine. The spatial resolution, overall efficiency and enhanced solid angle of the proposed detector will allow for more rapid and efficient collection of x-ray diffraction data with improved statistical accuracy. These features will directly impact our ability to solve new structures, and will allow for high resolution refinements which are critical for understanding chemistry and biology. The proposed detector system will complement the College's NIH funded Research Resource located at Brookhaven National Laboratory and will allow for optimal use of these facilities.