CORE--DEVELOPMENTAL

发展核心的主要目标有两个。第一，吸引 为艾滋病毒/艾滋病研究提供种子资金的新研究者 “新调查员奖”。第二，核心将支持试点项目 它涉及多学科的协同合作 Cf-CFAR成员。这些项目将获得4万至6万美元的直接 一年的费用。这可用于工资支持、技术支持 或者补给。四个计划的第一年奖项，由核心决定 主任杰里米·鲁班博士和核心小组委员会包括； 新研究员马克·穆辛(ADARC)研究遗传学和 HIV-1整合酶生物学；新研究员史蒂夫·格林伯格(哥伦比亚) 探索细胞凋亡与炎症的关系，新的研究者 Gerald Siu(哥伦比亚)将HHV-6与CD4的转录调控联系起来， 最后，新的调查员凯瑟琳·卡拉姆(哥伦比亚)调查 转录结合位点与HIV-1复制的相关性 原代单核/巨噬细胞。随后几年的项目资金将 由鲁班博士领导的核心小组委员会根据标准作出决定 选择包括：科学价值、对艾滋病毒/艾滋病和 CR-CFAR，符合发展核心的初衷。

The major goals of the Developmental Core are twofold. First, to attract new investigators to HIV/AIDS research by providing seed money in the form of "New Investigator Awards". Second, the Core will support pilot projects which involve synergistic, multi-disciplinary collaborations amongst the CF-CFAR members. These projects will receive $40,000 to 60,00 in direct costs for one year. This may be used for salary support, technical support or supplies. The four planned first year awards, as determined by the Core director Dr. Jeremy Luban and the Core sub-committee include projects by; new investigator Mark Muesing (ADARC) investigating the genetics and biology of HIV-1 integrase; new investigator Steve Greenberg (Columbia) probing the association of apoptosis and inflammation, new investigator Gerald Siu (Columbia) linking HHV-6 and transcriptional regulation of CD4, and finally new investigator Kathryn Calame (Columbia) investigating the association of transcriptional binding sites with HIV-1 replication in primary monocytes/macrophages. Project funding for subsequent years will be decided by the Core sub-committee headed by Dr. Luban with criteria for selection including; scientific merit, impact on both HIV/AIDS and the CR-CFAR, and conforming to the original intent of the Developmental Core.