课题基金 / 基金详情

NOVEL CYCLIC-PEPTIDE-BASED ANTIMITOTICS

NOVEL CYCLIC-PEPTIDE-BASED ANTIMITOTICS
新型环肽抗有丝分裂剂
批准号：
6179893
负责人：
Robert SCOTT LOKEY
金额：
$3.75万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
未结题
起止时间：
2000-07-01 至
来源：
https://reporter.nih.gov/project-details/6179893
关键词：
antimitotics chemical structure function cyclic peptides cyclins cytotoxicity membrane permeability peptide chemical synthesis peptide library

项目摘要

项目成果

Robert SCOTT LOKEY的其他基金

相似基金

相关文献

中文摘要
翻译
我们将合成一个小的七肽支架库，以探索支架构象对环化和细胞通透性的影响。我们将选择几种新的细胞渗透性循环支架，将其加工成潜在的蛋白质配体文库，并在许多不同的实验中筛选它们对细胞周期的影响。将选择几种活性化合物进行进一步研究。我们特别感兴趣的是通过直接干扰细胞周期蛋白B的降解或通过靶向有丝分裂纺锤体的成分从而触发有丝分裂检查点途径来阻止细胞有丝分裂的化合物。
英文摘要
We will synthesize a small library of heptapeptide scaffolds to explore the effects of scaffold conformation on cyclization and cell permeability. We will select several novel cell-permeable cyclic scaffolds for elaboration into libraries of potential protein ligands and screen them for effects on the cell cycle in a number of different assays. Several active compounds will be chosen for further study. We are particularly interested in compounds that arrest cells in mitosis by directly perturbing the degradation of cyclin B or by targeting components of the mitotic spindle and thus triggering the mitotic checkpoint pathway.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Advancing the basic science of membrane permeability in macrocyclic peptides
Upgrade of core imaging instrumentation and robotics for the UCSC Chemical Screening Center
Cyclic peptide permeability
Cyclic peptide permeability
海外基金