SACCADIC EYE MOVEMENT STUDIES

我们工作的最终目标是了解大脑 功能协调发展的 为此，我们研究输出（电机）部分，使用 以眼神经系统为模型。 我们对扫视眼的最新研究 运动（快速，步进式扫描眼球运动，我们用来“看” 在”我们的视觉世界“中）揭示了关于扫视如何 由神经扫视发生器编程 具体来说，我们展示了 舌下前置核（nph）和间质 Cajal核不能提供内部控制信号（局部 反馈），其指定正确的扫视大小。 因此，当前 必须对模型进行修改，以考虑到我们最近的结果和当地 反馈可以不用于控制扫视幅度 在眼科文献中被接受。 一旦眼睛到达它的 目标，它必须保持稳定，以提供明确的愿景。 这 是神经整合器的工作，一个假设的细胞核， 将速度编码指令转换为眼位放电， 从而在数学意义上对信号进行积分。 在另一 研究中，我们证实，nph，神经的假定位置， 积分器，产生眼睛命令信号，以产生稳定的 注视着古怪的眼睛位置。 然而，它显然没有被用于 由其他视觉子系统，如平滑的追求或 前庭眼系统，从而驳斥了共同的积分 假说. 这些结果是鉴别神经系统疾病的基础。 基于眼动体征的诊断现在通常在临床上用作 以及我们对眼神经过程的理解。 此外，本发明还提供了一种方法， 它们为研究更复杂的方面提供了基础， 中枢神经系统功能，如运动神经系统之间的相互作用， 系统（例如，在定向期间的眼睛和头部）或感觉和运动 系统（例如，视觉和视觉系统）以及更多 抽象的功能，如注意力和记忆力。 资助NIH赠款 RR 00166和EY 06558。 Kaneko角R. S.和福岛、K.放电 警觉猴前庭扫视神经元的特征。 J. 神经生理学 79 835-847，1998年。 Soetedjo河，Kaneko角R.美国，和 富克斯A. F. SC活动的时间不支持移动 希尔模型 神经科学学会 摘要24 418，1998年。

The ultimate goal of our work is to understand how the brain functions. To do this, we study the output ( motor) portions, using the oculomotor system as a model. Our recent studies of saccadic eye movements (the quick, step-like scanning eye movements we use to "look at" our visual world) have revealed new details about how saccades are programmed by the neural saccade generator. Specifically, we showed that the nucleus prepositus hypoglossi (nph) and the interstitial nucleus of Cajal cannot provide an internal control signal (local feedback) that specifies the correct saccade size. Thus, current models must be revised to account for our recent results and local feedback may not be used to control saccade amplitude as is commonly accepted in the oculomotor literature. Once the eye gets to its target, it must remain steady in order to provide clear vision. This is the job of the neural integrator, an hypothesized nucleus that converts velocity-coded commands into ey e-po sition discharge and thus integrates the signals in a mathematical sense. In another study, we confirmed that the nph, the putative location of the neural integrator, generates the oculomotor command signals to produce steady gaze at eccentric eye positions. However, it is apparently not used by the other oculomotor subsystems, such as the smooth pursuit or vestibulo-ocular systems, thus refuting the common integrator hypothesis. These results are basic to the differential neurological diagnosis based on eye movement signs now commonly used clinically as well as to our understanding of oculomotor processes. In addition, they provide a foundation for studies of more complex aspects of central nervous system function such as interactions between motor systems (e.g., eye and head during orientation) or sensory and motor systems (e.g., the visual and oculomotor systems) as well as more abstract functions such as attention and memory. FUNDING NIH grants RR00166 and EY06558. Kaneko, C. R. S. and Fukushima, K. Discharge characteristics of vestibular saccade neurons in alert monkeys. J. Neurophysiol. 79 835-847, 1998. Soetedjo, R., Kaneko, C. R. S., and Fuchs, A. F. The timing of SC activity does not support the moving hill model. Soc. Neurosci. Abstr. 24 418, 1998.