INTERACTIONS BETWEEN SIMIAN AIDS (SAIDS) & LEPROSY: MACAQUES

其余的恒河猴13只，来自之前的两项研究 对艾滋病病毒对麻风易感性的影响进行了尸检 并对麻风病进行了组织病理学评估。在13只动物中，有10只 代表对照动物接种麻风分枝杆菌(ML) 单独接种，3人在2-3年前接种ML和SIV 验尸报告。三只共同接种的动物中有两只呈艾滋病阳性，但 无法在这3只动物中确认麻风病；仅在10只ML中有1只 接种的动物呈麻风病阳性。的最终解释 因此，这些实验表明，20只动物中有16只接种了 SIV+ML出现麻风，而只接受ML的10只动物中只有1只出现麻风 在相同的观察时间内(2-3年)。这些结果 明确地表明，艾滋病病毒增加了对 恒河猴到麻风病。资助基础补助金，风险研究 出版物：Gormus BJ，徐凯，Baskin GB，Martin LN，Bohm Jr RP， Blanchard JL、Mack PA、Ratterree MS、Meyers WM和Walsh GP。 恒河猴实验性麻风病的传播、易感性 临床和免疫学结果。麻风回顾69：235-245,1998。 高慕斯，徐凯，墨菲-科布·M，马丁·林，巴斯金·GB，马克·PA， Ratterree MS、Gerone PJ、Scolard DM和Gillis TP。分枝杆菌 麻风与艾滋病病毒在猴子体内的相互作用。第15届国际麻风病 大会，北京，中国共和国，1998年9月10日。[摘要]

The remaining rhesus 13 monkeys from 2 prior studies of the effects of the AIDS virus on susceptibility to leprosy were necropsied and evaluated histopathologically for leprosy. Of the 13 animals, 10 represented control animals inoculated with Mycobacterium leprae (ML) alone and 3 were inoculated with ML and SIV 2-3 years prior to necropsy. Two of the 3 coinoculated animals were AIDS-positive but leprosy could not be confirmed in these 3 animals; 1 of the 10 ML-only inoculated animals was leprosy-positive. The final interpretation of these experiments, therefore, is that 16 of 20 animals inoculated with SIV + ML developed leprosy compared to 1 of 10 animals given ML only over the same time of observation (2-3 years). These results definitively show that the AIDS virus increases the susceptibility of rhesus monkeys to leprosy. FUNDING Base Grant, Venture Research PUBLICATIONS Gormus BJ, Xu K, Baskin GB, Martin LN, Bohm Jr RP, Blanchard JL, Mack PA, Ratterree MS, Meyers WM and Walsh GP. Experimental Leprosy in Rhesus Monkeys Transmission, Susceptibility, Clinical and Immunological Findings. Leprosy Review 69:235-245, 1998. Gormus BJ, Xu K, Murphey-Corb M, Martin LN, Baskin GB, Mack PA, Ratterree MS, Gerone PJ, Scollard DM and Gillis TP. Mycobacterium leprae-AIDS Virus Interactions in Monkeys. 15th International Leprosy Congress, Beijing, Republic of China, September 10, 1998. [Abstract]