LONG-TERM FUNCTIONING AND ALCOHOL TREATMENT--LAPSE AND RELAPSE IN ADOLESCENTS

该研究项目的长期目标是开发 预防和减少复吸问题的有效方法， 改变药物滥用的青少年。 该项目有四个 具体目标：（1）描述长期 * 长达5年）酒精（和 其他药物）使用和其他心理社会功能（例如，教育，使用 自由、时间、同伴关系）领域的合作 临床样本;（2）评估拟议的 根据成人文献改编的治疗后结果模型， 对物质使用和其他领域长期运作的解释， 以及PAARC临床研究中根据经验得出的复发定义 （3）在新的临床样本中研究 在以下情况下，酒精或其他药物使用失误/复发的诱发因素 人、治疗和环境决定因素;（4）进行 新临床样本中的失误和复发的事件历史分析。 受试者将是来自当前和新的PAARC临床研究的男性和女性 基线时符合DSM-IV当前酒精滥用标准的样本，或 依赖诊断 据估计，162，150和150青少年在 相同数量的男性和女性将符合入选标准， 这个项目从目前的PAARC队列，并将完成1-，3-， 和5年随访评估。 对应编号 1年和3年随访的新临床队列分别为130例和60例。 在相关的情况下，还将进行性别和年龄匹配的社区控制。 从临床中心取样用于分析目的。 除了 标准的PAARC评估方案，新的队列受试者， 构成部分将完成实现这一目标所需的其他措施 项目的具体目标。 此外，本研究中的新队列临床受试者 研究将每月进行一次电话采访，前12个 基线后6个月，重点关注日常酒精和其他药物使用， 治疗活动和复发促进剂。 数据分析将包括 描述性统计，使用单变量和 多变量检验、路径分析和事件历史分析。

The long-term goal of this research project component is to develop effective methods of preventing and reducing the problem of relapse in adolescents who have modified their substance abuse. The project has four specific aims: (1) To describe long-term *up to 5 years) alcohol (and other drug) use and other psychosocial functioning (e.g., education, use of free, time, peer relationships) areas in the current and new PAARC clinical samples; (2) To evaluate the adequacy of a variant of a proposed model of outcome following treatment adapted from the adult literature for the explanation of substance use and long-term functioning in other areas, and of empirically derived definitions of relapse in the PAARC clinical samples; (3) To study in the new clinical sample the immediate precipitant of alcohol or other drug use lapses/relapses, in the context of person, treatment, and environmental determinants; and (4) To conduct event history analyses of lapses and relapses in the new clinical sample. Subjects will be males and females from the current and new PAARC clinical samples who at baseline meet criteria for DSM-IV current alcohol abuse or dependence diagnosis. It is estimated that 162, 150, and 150 adolescent in equal numbers of males and females will have met criteria for inclusion in this project from the current PAARC cohort and will have completed 1-,3-, and 5-year follow-up assessments, respectively. Counterpart numbers for the new clinical cohort are 130 and 60 for the 1- and 3-year follow-ups. Where relevant, gender- and age-matched community controls also will be sampled from the clinical core for purposes of analysis. In addition to the standard PAARC assessment protocol, new cohort subjects in this component will complete additional measures required to achieve this project's specific aim. In addition, new cohort clinical subjects in this study will be administered monthly telephone interviews for the first 12 months post baseline that focus on daily alcohol and other drug use, treatment activities, and relapse precipitants. Data analyses will include descriptive statistics, comparison of group means by use of univariate and multivariate tests, path analysis, and event history analyses.