ACTG 247:INCREASED CALORIC FORMULA EFFECT ON GROWTH & NUTRITION ON HUM INFANTS

这项试验旨在评估浓缩婴儿配方奶粉与标准婴儿配方奶粉对感染艾滋病毒婴儿的体重增加、生长发育和营养状况的影响。主要的具体目标是确定感染艾滋病毒的婴儿在出生后14天内开始补充卡路里是否会改善出生28周时的体重或身长。第二个具体目标是a)确定营养补充对头围的影响，作为大脑发育、免疫状况、机会性感染和生活质量的指标，以及b)评估浓缩配方奶粉与标准配方奶粉相比在感染艾滋病毒的婴儿中的长期耐受性(28周)，以及浓缩配方奶粉与所有暴露于艾滋病毒的婴儿的标准配方奶粉相比的短期耐受性(8周)。

This trial is designed to evaluate the effect of concentrated infant formula compared with standard infant formula on weight gain, growth and nutritional status in HIV-infected infants. The primary specific aim is to determine if caloric supplementation in HIV-infected infants, started within the first 14 days of life, results in improved growth as measured by weight or length at 28 weeks. The secondary specific aim is to a) determine the effect of nutritional supplementation on head circumference as an indicator of cerebral growth; immune status; opportunistic infection; and quality of life, and b) to evaluate the long term tolerability (28 weeks) of a concentrated formula compared to a standard formula in HIV-infected infants and the short term tolerability (8 weeks) of a concentrated formula compared to a standard formula in all HIV-exposed infants.