TEST EFFECT OF EFFECT OF NFV, RTV & SOFT GEL SQV

本研究的目的是确定三种HIV蛋白酶抑制剂的生物利用度是否受到同时给药的影响，而不是分开几小时给药。正在测试的假设是，由于这些化合物中至少有两种是p -糖蛋白的抑制剂，因此两种蛋白酶抑制剂的共同施用可能通过阻止p -糖蛋白将其运输出肠细胞来增加两者的生物利用度。设计是一个平衡的拉丁方形，以尽量减少科目和分析。同时给药和交错给药后取血浆样品，用高效液相色谱法分析药物浓度。标准的非室室药代动力学分析将用于确定效果，如果任何不同的时间给药。该方案的登记工作现已完成，样本已收集，实验室化验和数据分析正在进行中。目前还没有初步结果。

The purpose of this study is to determine whether the bioavailability of the three HIV protease inhibitors is affected by giving them together in contrast to separating the doses by several hours. The hypothesis being tested is that since at least two of these compounds are inhibitors of P-glycoprotein, co-administration of two protease inhibitors may increase the bioavailability of both by preventing their transport out of intestinal cells by P-glycoprotein. The design is a balanced Latin square, in an effort to minimize subjects and assays. Plasma samples are obtained after simultaneous and staggered dosing, and analyzed for drug concentration by HPLC. Standard non-compartmental pharmacokinetic analysis will be used to determine the effect, if any of the different times of administration. Enrollment in the protocol is now complete, samples have been collected, and laboratory assays and data analyses are ongoing. There are no preliminary results available at the present time.