EARLY ADMINISTRATION OF BECLOMETHASONE IN PREMATURE NEONATES AT RISK FOR BPD

支气管肺发育不良（BPD）是一种常见的肺部并发症， 早产 治疗呼吸机依赖性的主要目的 早产儿是为了尽量减少慢性肺损伤相关的 波士顿警局 因此，呼吸机支持和氧气补充必须 迅速减少。研究表明， 地塞米松加速了这一结果。 然而，皮质类固醇大多数 通常仅在发生显著的肺部 损害，即。在出生后两到四周之间。 我们将评估 吸入倍氯米松的效果，在前5天内开始 对肺功能、肺部炎症和 机械通气治疗早产儿重症呼吸道感染 痛苦综合症 这是第一项评估效率和 吸入性类固醇的不良反应在病理学早期就开始了， 和炎症过程。

Bronchopulmonary dysplasia (BPD) is a common pulmonary complication of prematurity. A primary objective in treating ventilator-dependent premature infants is to minimize chronic lung damamge associated with BPD. Ventilaator support and oxygen supplementation must therefore be reduced expeditiously. Studies have demonstrated that intravenous dexamethasone hastens this outcome. However, corticosteroids ae most commonly initiated only after the development of significant lung damage, ie. between two and four weeks after birth. We will assess the effect of inhaled beclomethasone, inititated within the first 5 days of life, on pulmonary function, pulmonary inflammation, and duration of mechanical ventilation in premature neonates with severe respiratory distress syndrome. This is the first study to assess the efficiacy and adverse effects of inhaled steroids initiated early in the pathologic and inflammatory process.