课题基金 / 基金详情

PHASE I/II DOSING SAFETY AND ANTIVIRAL ACTIVITY OF HYDROSYUREA ALONE/COMBINED

PHASE I/II DOSING SAFETY AND ANTIVIRAL ACTIVITY OF HYDROSYUREA ALONE/COMBINED
单独/联合使用氢脲的 I/II 期给药安全性和抗病毒活性
批准号：
6219898
负责人：
GILDON N BEALL
金额：
$0.1万
依托单位：
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6219898
关键词：
2'3' dideoxyinosine AIDS therapy HIV infections antiAIDS agent antiviral agents clinical research clinical trial phase I combination chemotherapy dosage drug screening /evaluation gastrointestinal drug absorption human immunodeficiency virus human subject human therapy evaluation hydroxyurea outcomes research virus load

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中文摘要
翻译
为了测试两种剂量的药物羟基脲单独或与另一种药物DDI一起服用对艾滋病毒感染者的安全性。这项研究还将观察单独服用羟基脲或与DDI联合服用是否与单独服用DDI相比，减少艾滋病毒感染者血液中的病毒数量。此外，还将研究DDI和羟基尿素是如何被人体吸收的。羟基脲已经被大量用于镰状细胞患者，但它在艾滋病毒感染者中的使用是新的，而且受到限制。
英文摘要
To test the safety of two doses of a drug, hydroxyurea, given alone or together with another drug, DDI, in persons infected with the HIV. This study also will see if hydroxyurea given alone or together with DDI decreases the amount of virus in the blood of HIV-infected persons as compared to DDI given alone. In addition, how DDI and hydroxyurea are absorbed into the body will also be looked at. Hydroxyurea has been used in a large number of sickle cell patients, but its use in HIV-infected persons is new and has been limited
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会议论文
ACTG 328--RECOMBINANT HUMAN IL 2 BY IV OR SC IN HIV PATIENTS ON HAART
ACTG388 EFAVIRENZ OR NELFINAVIR IN COMBINATION W/ FIXED DOSE COMBINAT
PHYSIOLOGIC TESTOSTERONE REPLACEMENT IN HIV INFECTED WOMEN
PHASE I/II DOSING SAFETY AND ANTIVIRAL ACTIVITY OF HYDROSYUREA ALONE/COMBINED
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