GROWTH AND NUTRITIONAL STATUS IN CHILDREN WITH SICKLE CELL ANEMIA

这项研究包括三个项目，研究增长的各个方面， 镰状细胞病（SCD）儿童的营养和营养， 这些参数与临床状态的相互作用。虽然增长 先前已经描述了患有SCD的儿童的缺陷， 营养和疾病相关因素知之甚少。在这 研究，我们：项目1：纵向评估的增长，发展， 营养状况和膳食摄入量的150名SCD患者，年龄出生至 18年，及其与临床状态的关系;项目2：评估 能量平衡的儿童（5至18岁）与SCD，通过评估 休息和总能量消耗和饮食摄入，而在一个平常的 健康状况与对照组儿童;项目3：评估精力充沛的 通过测量静息能量消耗（REE）计算急性疾病的成本 SCD儿童住院期间的饮食摄入量 与他们平时的健康状况相比，急性疾病发作。

This study consists of three projects that examine aspects of the growth and nutrition of children with sickle cell disease (SCD) and the interaction of these parameters with clinical status. Although the growth deficits of children with SCD have been previously described, the nutritional and disease related factors are poorly understood. In this study, we: Project 1: evaluate longitudinally the growth, development, nutritional status, and dietary intake of 150 SCD patients, ages birth to 18 years, and its relationship to clinical status; Project 2: assess energy balance in children (5 to 18 years old) with SCD by evaluating resting and total energy expenditure and dietary intake while in a usual state of health vs. control children; and Project 3: assess the energetic cost of acute illness by measuring the resting energy expenditure (REE) and dietary intake of children with SCD during hospitalization for an acute illness episode compared to their usual state of health.