NORTH AMERICAN GROWTH IN CEREBRAL PALSY--PILOT DEXA PROJECT

审查目标：北美脑瘫生长项目（NAGCePP）是一项针对脑瘫生长的多中心（美国4家研究中心和加拿大2家研究中心）研究。 已确定的长期目标和具体研究假设被划分为项目的三个阶段：第一阶段：制定方案;第二阶段：试点/可行性研究;第三阶段：正式项目：制定增长图表。 我们刚刚完成了该项目核心部分的第二阶段，并根据这一试点人类学数据向即将举行的会议提交了摘要。 核心研究是一项以人群为基础的CP儿童样本的人体测量学研究，所有中心都提供了数据。 此外，个别研究中心参与了正在进行的嵌套研究，这些研究使用了小个子样本，只有个别研究中心（或少数研究中心）提供了数据。 这些巢式研究解决了与生长、营养状况及其对功能状况和生活质量的影响相关的更具体的问题。 该提案涉及在我们的地理区域（费城）启动的骨密度嵌套试点研究。骨密度巢式研究的具体目的如下：1. 在北美四个地理区域收集一个具有代表性的、基于人群的CP儿童样本的骨密度试验数据。 2.收集基线时骨折风险因素的数据（例如钙摄入量、体型、骨矿物质代谢标志物、药物和活动水平）3。 收集骨折发生率的纵向数据（通过电话随访）。 4. 比较脑瘫儿童与非脑瘫健康儿童股骨远端骨密度的结果。

Review of Aims: The North American Growth in Cerebral Palsy Project (NAGCePP) was developed as a multi-center (4 sites within the United States and 2 sites in Canada) study of growth in cerebral palsy. The identified long-term goals and specific hypotheses for study were delineated into three phases of the project: Phase I: protocol development; Phase II: pilot/feasibility study and Phase III: the formal project: development of growth charts. We have just completed Phase II of the core part of this project, and have submitted abstracts to upcoming meetings based on this pilot anthropological data. The core study was an anthropometric study of growth in a population-based sample of children with CP to which all centers have contributed data. Additionally, individual centers have participated in ongoing nested studies utilizing small sub-samples to which only that individual site (or a few sites) have contributed data. These nested studies have addressed more specific questions related to growth, nutritional status, and their effects on functional status and quality of life. This proposal addresses the nested pilot study of bone mineral density that was initiated at our geographical region (Philadelphia). The specific aims of the Bone Density Nested Study were as follows: 1. To collect pilot data on bone density in a representative, population-based sample of children with CP in four geographic areas in North America. 2. To collect data on risk factors for bone fracture at baseline (e.g. calcium intake, body size, markers of bone mineral metabolism, medications and level of mobility) 3. To collect longitudinal data (by follow-up phone call) on fracture incidence. 4. To compare the results of bone mineral density at the distal femur from children with Cerebral Palsy to healthy children without Cerebral Palsy.