NICOTINE PATCH TREATMENT AS AN ANORECTIC

这是一个随机，双盲安慰剂对照研究透皮尼古丁对人体代谢的影响。评估的结果包括经皮尼古丁对间接量热法测得的静息能量消耗、DEXA扫描测得的身体成分、报告的热量摄入和活动的影响。到目前为止，有198人打电话表示对这项研究感兴趣。其中，64人通过了电话筛查，31人通过了额外的测试和身体检查。18人完成了这项研究。3名受试者因恶心、呕吐和头晕等不良反应退出研究。我们预计将于1999年9月30日完成这项研究。数据分析正在等待研究完成。我们现正评估直接以电子方式传送数据的可行性，以方便分析。

This is a randomized, double-blind placebo controlled study of the effects of transdermal nicotine on human metabolism. The outcomes being assessed include the effects of transdermal nicotine on resting energy expenditure measure by indirect calorimetry, body composition measured by DEXA scan, reported caloric intake and activity. To date, 198 individuals called expressing an interest in the study. Of those, 64 passed phone screen and 31 were eligible after additional testing and physical examination. Eighteen have completed the study. Three subjects dropped from the study due to adverse effects including nausea, vomiting, and dizziness. We anticipate completion of the study by 9/30/99. Data analysis is pending completion of the study. We are currently assessing the feasibility of direct electronic transfer of data to facilitate analysis.