PULMONARY ASPERGILLOMA

主要目的-比较伊曲康唑口服液环糊精与安慰剂（羟丙基-β-环糊精）治疗肺曲菌球的安全性和有效性。 具体目标：1。 评价伊曲康唑口服液环糊精包合物治疗肺曲菌球的疗效和安全性。2. 确定血清伊曲康唑药物水平与预后之间的关系。3. 确定曲菌瘤患者亚群，通过伊曲康扎芦荟环糊精口服溶液治疗，在发病率和死亡率方面获益。

Main Objective- to compare the safety and efficacy of itraconazole oral solution in cyclodextrin with placebo (hydroxypropyl-B-cyclodextrin) in the treatment of pulmonary aspergilloma. Specific Objectives: 1. To evaluate the efficacy and safety of itraconazole oral solution in cyclodextrin in the treatment of patients with pulmonary aspergilloma. 2. To determine association between serum itraconazole drug levels and outcome. 3. To identify subpopulations of patients with aspergilloma that would benefit in terms of morbidity and mortality by treatment with itraconzaloe oral solution in cyclodextrin.