CHEMOSENSORY CLINICAL RESEARCH

Monell-Jefferson Chemosensory临床研究中心（CCRC） 包括蒙乃尔化学传感器公司的科学家们 中心和医生在托马斯杰斐逊大学。 协同 项目也存在与医生在医学院， 宾夕法尼亚州威尔斯眼科医院和退伍军人事务医疗中心 位于费城 CCRC致力于科学研究 味觉和嗅觉的临床障碍，以及基础研究， 化学感官。 通过临床多学科研究， 人口，CCRC科学家希望表征和了解 化学感觉功能障碍的病因学，提供信息 化学感官在人类中的机制和功能， 治疗/应对化学感觉障碍的策略。 CCRC的拟议更新将包括一个行政核心 单位，一个感官核心单位（负责监督所指的评估） 原发性化学感觉障碍的患者），以及5例 个人研究项目。 CCRC的总体目标是：1） 继续提供诊所设施， 化学感觉障碍及其病因和病症的研究， 特别关注失真综合征（嗅觉障碍和味觉障碍）; 2)研究正常和异常的人类嗅觉功能， 和分子水平，应用敏感的电生理学， 生物物理和分子生物学技术应用于人类嗅觉活检 材料; 3）确定盐敏感性的非侵入性指标， 制定有效的饮食干预策略， 高血压的风险; 4）启动性质的研究， 药物相关味觉功能障碍的生理基础，重点是 口腔感觉知觉障碍与使用 碳酸酐酶抑制剂; 5）继续探索功能 鼻三叉神经的特征和个体变异 刺激嗅觉正常和嗅觉缺失个体;和6）评估 代谢紊乱性三甲基氨基尿与 化学感觉，检查这种疾病的生化基础， 探讨生化缺陷的分子遗传学。

The Monell-Jefferson Chemosensory Clinical Research Center (CCRC) involves a collaboration between scientists at the Monell Chemical Senses Center and physicians at Thomas Jefferson University. Collaborative projects also exist with physicians at the Medical College of Pennsylvania, Wills Eye Hospital and the Veterans Affairs Medical Center of Philadelphia. The CCRC is devoted to the scientific examination of clinical disorders in taste and smell, as well as to basic research in the chemical senses. Through the multidisciplinary study of clinical populations, CCRC scientists expect to characterize and understand the etiologies of disorders in chemosensory function, provide information on mechanisms and functions of the chemical senses in humans, and develop strategies for treating/coping with chemosensory disorders. The proposed renewal of the CCRC will comprise an Administrative Core unit, a Sensory Core unit (which oversees the evaluation of referred patients with primary complaints of chemosensory disorders), and five individual research projects. The general aims of the CCRC will be: 1) to continue to provide a clinic facility for the evaluation of chemosensory disorders and the study of their etiologies and prognoses, with a specific focus on distortion syndromes (dysosmia and dysgeusia); 2) to study normal and abnormal human olfactory function at the cellular and molecular levels, applying sensitive electrophysiological, biophysical and molecular biological techniques to human olfactory biopsy material; 3) to identify non-invasive indices for salt sensitivity and to develop effective dietary intervention strategies for individuals at risk for hypertension; 4) to initiate studies of the nature and physiological bases of drug-related taste dysfunction, with focus on disturbances in oral sensory perception associated with the use of carbonic anhydrase inhibitors; 5) to continue to explore the functional characteristic of, and individual variations in, nasal trigeminal stimulation in both normosmic and anosmic individuals; and 6) to evaluate the relationships between the metabolic disorder trimethylaminuria and chemosensation, examine the biochemical basis of this disorder and explore the molecular genetics of the biochemical defect.