CORE--ANIMAL MODELS

动物模型中心于1985年由美国医学会 动物护理（DAC）。 该资源发挥了重要作用， 俄勒冈州生物医学研究的持续增长和成功 健康科学大学通过减少重复的需要， 设备、空间和支持人员。DAC增加了几个新的 动物模型自1985年以来 1993年，第二只转基因小鼠 增加了一个实验室，以满足OHS的额外要求 investigators. 核心设施的具体目标是：1）协助 癌症中心的研究人员在开发和表征 生物医学相关的动物模型; 2）提供癌症中心 研究人员使用DNA显微镜对无病原体转基因小鼠进行了研究， 注射和胚胎干细胞转移方法; 3）提供一种 保持无病原体的质量管理计划 免疫缺陷动物模型如裸鼠、裸鼠、SCID 小鼠和辐照小鼠; 4）维持转基因动物系， 质量育种计划，检疫，重新衍生的股票，和 冷冻保存; 5）提供咨询来源， 对癌症中心研究人员进行转基因设计的培训 和其他动物模型研究。

The Animal Models Core was established in 1985 by the Department of Animal Care (DAC). The resource has played a major role in the continued growth and success of biomedical research at the Oregon Health Sciences University by reducing the need for duplication of equipment, space, and support staff. The DAC has added several new animal models since 1985. In 1993, a second transgenic mouse laboratory was added to meet additional requirements of OHS investigators. The specific goals of the Core facility are: 1) to assist Cancer Center investigators in the development and characterization of biomedically relevant animal models; 2) to provide Cancer Center investigators with pathogen free transgenic mice using DNA micro injection and embryonic stem cell transfer methods; 3) to provide a quality husbandry program for the maintenance of pathogen free immunodeficient animal models such as nude mice, nude rats, scid mice, and irradiated mice; 4) to maintain transgenic animal lines with quality breeding programs, quarantine, re-derivation of stocks, and cryopreservation; and 5) to provide a source of consultation and training to Cancer Center investigators about the design of transgenic and other animal model studies.