CHEMOSENSORY CLINICAL RESEARCH

莫奈尔-杰斐逊化学传感临床研究中心(CCRC) 涉及莫内尔化学感知器的科学家之间的合作 托马斯·杰斐逊大学的中心和内科医生。协作性 还存在与麻省理工学院医学院的医生合作的项目 宾夕法尼亚州威尔斯眼科医院和退伍军人事务医疗中心 来自费城。中国保监会致力于科学审查 临床味觉障碍，以及基础研究 这种化学物质能感觉到。通过对临床的多学科研究 ，CCRC的科学家们希望描述和理解 化学感觉功能障碍的病因，提供关于 人类化学感官的机制和功能，并发展 治疗/应对化学感觉障碍的策略。 建议的中国商业汇报局更新将包括一个行政核心 单位，感官核心单位(监督推荐的评估 以化学感觉障碍为主诉的患者)，以及五 个人研究项目。中国证监会的总体目标是：1) 继续提供诊所设施，以评估 化学感觉障碍及其病因和预后的研究， 特别关注扭曲综合症(嗅觉障碍和构音障碍)； 2)在细胞水平上研究正常和异常的人类嗅觉功能 和分子水平，应用灵敏的电生理， 生物物理和分子生物学技术在人类嗅觉活检中的应用 材料；3)确定盐敏感性的非侵入性指标和 为个人制定有效的饮食干预策略 患高血压的风险；4)启动对自然和 药物相关性味觉功能障碍的生理基础，重点是 与使用药物有关的口腔感觉障碍 碳酸酐酶抑制剂；5)继续探索功能性 鼻三叉神经的特点和个体变异 对正常个体和无渗透个体的刺激；以及6)评估 代谢紊乱与三甲基氨基尿症的关系 化学感觉，检查这种疾病的生化基础和 探讨生化缺陷的分子遗传学。

The Monell-Jefferson Chemosensory Clinical Research Center (CCRC) involves a collaboration between scientists at the Monell Chemical Senses Center and physicians at Thomas Jefferson University. Collaborative projects also exist with physicians at the Medical College of Pennsylvania, Wills Eye Hospital and the Veterans Affairs Medical Center of Philadelphia. The CCRC is devoted to the scientific examination of clinical disorders in taste and smell, as well as to basic research in the chemical senses. Through the multidisciplinary study of clinical populations, CCRC scientists expect to characterize and understand the etiologies of disorders in chemosensory function, provide information on mechanisms and functions of the chemical senses in humans, and develop strategies for treating/coping with chemosensory disorders. The proposed renewal of the CCRC will comprise an Administrative Core unit, a Sensory Core unit (which oversees the evaluation of referred patients with primary complaints of chemosensory disorders), and five individual research projects. The general aims of the CCRC will be: 1) to continue to provide a clinic facility for the evaluation of chemosensory disorders and the study of their etiologies and prognoses, with a specific focus on distortion syndromes (dysosmia and dysgeusia); 2) to study normal and abnormal human olfactory function at the cellular and molecular levels, applying sensitive electrophysiological, biophysical and molecular biological techniques to human olfactory biopsy material; 3) to identify non-invasive indices for salt sensitivity and to develop effective dietary intervention strategies for individuals at risk for hypertension; 4) to initiate studies of the nature and physiological bases of drug-related taste dysfunction, with focus on disturbances in oral sensory perception associated with the use of carbonic anhydrase inhibitors; 5) to continue to explore the functional characteristic of, and individual variations in, nasal trigeminal stimulation in both normosmic and anosmic individuals; and 6) to evaluate the relationships between the metabolic disorder trimethylaminuria and chemosensation, examine the biochemical basis of this disorder and explore the molecular genetics of the biochemical defect.